Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 3/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401588 | 0.87 | NAALAD2 (0.42) | CYP2C9LMNACYP2C19MEN1KMT2A | |
| SCHEMBL7366777 | 0.85 | HSD11B1 (0.42) | MEN1KMT2ACYP1A2HSD11B1 | |
| SCHEMBL7396691 | 0.85 | TSHR (0.36) | CYP2C9LMNACYP2C19MEN1KMT2A | |
| SCHEMBL7364668 | 0.85 | ANPEP (0.37) | CYP2C9LMNACYP2C19MEN1KMT2A | |
| SCHEMBL7361675 | 0.85 | CA1 (0.41) | KMT2ACYP1A2SLC6A9HSD11B1RAB9A | |
| SCHEMBL7361098 | 0.82 | MAPK1 (0.37) | CYP2C19FFAR1 | |
| SCHEMBL7360108 | 0.80 | GPR88 (0.42) | CYP2C9CYP2C19CYP3A4CYP1A2TSHR | |
| SCHEMBL7363033 | 0.79 | ALDH1A1 (0.36) | CYP2D6CYP2C19MEN1KMT2ACYP1A2 | |
| SCHEMBL7367347 | 0.79 | GRM2 (0.37) | CYP2C9LMNACYP2C19MEN1KMT2A | |
| SCHEMBL7364859 | 0.77 | ANPEP (0.43) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |