Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364668 | 0.85 | ANPEP (0.37) | ANPEPGRM2GRM3APEX1ALDH1A1 | |
| SCHEMBL7400114 | 0.85 | SLC6A9 (0.41) | GRM2GRM3ALDH1A1CYP1A2GRIK2 | |
| SCHEMBL7365727 | 0.85 | SLC6A9 (0.41) | GRM2GRM3ALDH1A1CYP1A2 | |
| SCHEMBL7362964 | 0.81 | FFAR1 (0.45) | GRM2GRM3 | |
| SCHEMBL7401588 | 0.78 | NAALAD2 (0.42) | GRM2GRM3APEX1ALDH1A1CYP1A2 | |
| SCHEMBL7366777 | 0.77 | HSD11B1 (0.42) | GRM2GRM3ALDH1A1CYP1A2FOLH1 | |
| SCHEMBL7399249 | 0.77 | GABBR2 (0.39) | CYP1A2 | |
| SCHEMBL7396691 | 0.77 | TSHR (0.36) | GRM2GRM3APEX1ALDH1A1CYP1A2 | |
| SCHEMBL7361675 | 0.77 | CA1 (0.41) | ALDH1A1CYP1A2GRIK2CA1CA2 | |
| SCHEMBL7367347 | 0.74 | GRM2 (0.37) | GRM2GRM3APEX1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |