Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396691 | 0.85 | TSHR (0.36) | ALDH1A1CYP1A2FFAR1FFAR4LMNA | |
| SCHEMBL7364859 | 0.85 | ANPEP (0.43) | ALDH1A1CYP1A2GRM2GRM3 | |
| SCHEMBL7400114 | 0.85 | SLC6A9 (0.41) | SLC6A9TDP1ALDH1A1CYP1A2FFAR1 | |
| SCHEMBL7362964 | 0.81 | FFAR1 (0.45) | TDP1L3MBTL1FFAR1LMNAGRM2 | |
| SCHEMBL7401588 | 0.78 | NAALAD2 (0.42) | ALDH1A1CYP1A2FFAR1LMNAGRM2 | |
| SCHEMBL7361675 | 0.77 | CA1 (0.41) | SLC6A9L3MBTL1ALDH1A1CYP1A2FFAR1 | |
| SCHEMBL7366777 | 0.77 | HSD11B1 (0.42) | ALDH1A1CYP1A2GRM2GRM3 | |
| SCHEMBL7399249 | 0.77 | GABBR2 (0.39) | SLC6A9CYP1A2FFAR1LMNA | |
| SCHEMBL7364668 | 0.77 | ANPEP (0.37) | TDP1ALDH1A1CYP1A2FFAR1LMNA | |
| SCHEMBL7367347 | 0.74 | GRM2 (0.37) | ALDH1A1CYP1A2LMNAGRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |