Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363033 | 0.84 | ALDH1A1 (0.36) | NOTUMFFAR1CYP2C19CACNA1GCACNA2D1 | |
| SCHEMBL7399249 | 0.82 | GABBR2 (0.39) | FFAR1CYP2C19 | |
| SCHEMBL7367783 | 0.77 | HTT (0.37) | MAPK1FFAR1 | |
| SCHEMBL7363863 | 0.74 | CNR2 (0.36) | CYP2C19 | |
| SCHEMBL7401588 | 0.72 | NAALAD2 (0.42) | FFAR1CYP2C19 | |
| SCHEMBL7368272 | 0.72 | CYP2C19 (0.41) | TDP1CYP2C19 | |
| SCHEMBL7366777 | 0.71 | HSD11B1 (0.42) | CACNA1B | |
| SCHEMBL7361675 | 0.71 | CA1 (0.41) | FFAR1 | |
| SCHEMBL7396691 | 0.71 | TSHR (0.36) | FFAR1CYP2C19 | |
| SCHEMBL7364668 | 0.71 | ANPEP (0.37) | TDP1FFAR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |