Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401588 | 0.80 | NAALAD2 (0.42) | GRM2GRM3ALDH1A1CYP1A2SLC1A2 | |
| SCHEMBL7399249 | 0.79 | GABBR2 (0.39) | CYP1A2CYP2C9CYP2C19LMNAMEN1 | |
| SCHEMBL7396691 | 0.79 | TSHR (0.36) | GRM2GRM3ALDH1A1CYP1A2SLC1A2 | |
| SCHEMBL7361675 | 0.79 | CA1 (0.41) | ALDH1A1CYP1A2KMT2A | |
| SCHEMBL7366777 | 0.79 | HSD11B1 (0.42) | GRM2GRM3ALDH1A1CYP1A2MEN1 | |
| SCHEMBL7364668 | 0.79 | ANPEP (0.37) | GRM2GRM3ALDH1A1CYP1A2SLC1A2 | |
| SCHEMBL7360789 | 0.76 | PDE4B (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7364354 | 0.76 | CES2 (0.37) | GRM2GRM3ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7364859 | 0.74 | ANPEP (0.43) | GRM2GRM3ALDH1A1CYP1A2APEX1 | |
| SCHEMBL7400114 | 0.74 | SLC6A9 (0.41) | GRM2GRM3ALDH1A1CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |