Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.38 |
| ▸ | ITGAV | P06756 | 12/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8467659 | 0.89 | GABRG2 (0.39) | ITGB3ITGA2BITGAVKLK7 | |
| SCHEMBL7544674 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BITGAVMAPTHPGD | |
| SCHEMBL8468002 | 0.83 | DHODH (0.37) | ITGB3ITGA2BITGAVKLK7 | |
| SCHEMBL8323234 | 0.83 | KLK7 (0.36) | ITGB3ITGA2BKLK7 | |
| SCHEMBL8467321 | 0.81 | GABRA1 (0.35) | KLK7 | |
| SCHEMBL5155939 | 0.81 | ITGB3 (0.41) | ITGB3ITGA2BITGAVMAPTHPGD | |
| SCHEMBL7798122 | 0.77 | HSD17B3 (0.39) | ITGB3ITGA2BITGAVMAPTHPGD | |
| SCHEMBL8328325 | 0.75 | ITGB3 (0.40) | ITGB3ITGA2BITGAVHPGD | |
| SCHEMBL8330616 | 0.74 | ITGB3 (0.46) | ITGB3ITGA2BITGAV | |
| SCHEMBL6840064 | 0.74 | ITGB3 (0.36) | ITGB3ITGA2BITGAVMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767792-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5977101-A | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0767792-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000730-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |