Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370004 | 0.89 | DRD2 (0.50) | DRD4DRD2DRD3MAPK1HSD17B10 | |
| SCHEMBL7369485 | 0.85 | MAPK1 (0.58) | MAPK1HSD17B10SIGMAR1 | |
| SCHEMBL28610812 | 0.81 | LTA4H (0.58) | DRD4DRD2DRD3LTA4HSIGMAR1 | |
| SCHEMBL29995464 | 0.81 | LTA4H (0.58) | DRD4DRD2DRD3LTA4HSIGMAR1 | |
| SCHEMBL7370205 | 0.81 | CCR1 (0.56) | DRD4DRD2DRD3MAPK1F10 | |
| SCHEMBL8489397 | 0.81 | ALDH1A1 (0.50) | DRD4DRD2DRD3MAPK1LTA4H | |
| SCHEMBL7374884 | 0.80 | SPIN1 (0.54) | SIGMAR1 | |
| SCHEMBL1333135 | 0.77 | SIGMAR1 (0.56) | DRD2DRD3LTA4HSIGMAR1ALDH1A1 | |
| SCHEMBL7376797 | 0.77 | MAPK1 (0.60) | MAPK1HSD17B10LTA4HSIGMAR1ALDH1A1 | |
| SCHEMBL5063868 | 0.77 | CCR1 (0.56) | DRD4DRD2DRD3MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |