SCHEMBL7426519

SCHEMBL7426519

O=C(O)CCN1CC(=O)N(C(CS)Cc2ccccc2)C1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MME P08473 6/20 0.42
ACE P12821 4/20 0.42
CPA3 P15088 2/20 0.41
FOLH1 Q04609 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
SIRT1 Q96EB6 1/20 0.41
ENPP2 Q13822 1/20 0.40
ALDH1A1 P00352 3/20 0.40
PKM P14618 1/20 0.40
HSD17B10 Q99714 2/20 0.39
MEN1 O00255 2/20 0.39
MAPT P10636 2/20 0.39
KMT2A Q03164 2/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
ECE1 P42892 1/20 0.39
BLM P54132 1/20 0.39
NPEPPS P55786 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7435994 0.93 MME (0.41) MMEACECPA3FOLH1ENPP2
SCHEMBL7428787 0.88 KMT2A (0.45) MMEACECPA3FOLH1ENPP2
SCHEMBL7432640 0.83 ENPP2 (0.47) CPA3FOLH1TSHRENPP2ALDH1A1
SCHEMBL7445692 0.79 ENPP2 (0.36) MMECPA3FOLH1ENPP2ALDH1A1
SCHEMBL7426522 0.78 MAPT (0.43) KDM4EALOX15TSHRSIRT1ENPP2
SCHEMBL7428452 0.78 PLA2G10 (0.45) CPA3FOLH1KDM4EENPP2ALDH1A1
SCHEMBL7442303 0.77 ALDH1A1 (0.53) CPA3FOLH1KDM4EALOX15TSHR
SCHEMBL7446522 0.76 CPA3 (0.44) MMECPA3FOLH1ALOX15ALDH1A1
SCHEMBL7440464 0.76 FOLH1 (0.41) MMEACECPA3FOLH1ALDH1A1
SCHEMBL7440724 0.74 HRH4 (0.43) ENPP2ALDH1A1MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640594-A1 Hydantoin derivative as metalloprotease inhibitor FUJIREBIO INC. (JP) 1995-03-01 EP disclosed