Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434571 | 0.94 | ADAM17 (0.37) | ADAM17SMN1; SMN2PRSS1PRSS2PRSS3 | |
| SCHEMBL7433554 | 0.91 | CTSL (0.40) | SMN1; SMN2CTSBCTSSCTSKPOLB | |
| SCHEMBL7444104 | 0.87 | CTSK (0.46) | SMN1; SMN2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL7435520 | 0.79 | MME (0.41) | ADAM17KMT2ATSHR | |
| SCHEMBL7428167 | 0.79 | MMP8 (0.43) | SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL7341910 | 0.77 | MEN1 (0.42) | ADAM17SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL7433267 | 0.77 | CTSL (0.54) | CTSBCTSSCTSK | |
| SCHEMBL7434588 | 0.77 | PPARG (0.36) | CYP2C9CYP2C19CTSBCTSSPOLB | |
| SCHEMBL7351604 | 0.76 | MMP8 (0.39) | CYP2C9CYP2C19KMT2A | |
| SCHEMBL7432459 | 0.76 | CHRNB2 (0.38) | CYP2C9CYP2C19CTSBCTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5312826-A | Dicarboxylic acids with hypotensive agents and cardiovascular disorders | TANABE SEIYAKU CO., LTD. (JP) | 1994-05-17 | — | — | US | disclosed |
| EP-0519738-A1 | Dicarboxylic acid derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1992-12-23 | — | — | EP | disclosed |