Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289664 | 0.87 | CHRM2 (0.43) | THRBTHRACHRM2CHRM1 | |
| SCHEMBL7429204 | 0.83 | SPHK1 (0.41) | THRBTHRAALDH1A1HSD17B10 | |
| SCHEMBL7434257 | 0.81 | EPHX1 (0.40) | CHRM2CHRM1LMNAKMT2A | |
| SCHEMBL7435074 | 0.79 | CA2 (0.41) | CA2CYP2C19 | |
| SCHEMBL7435723 | 0.78 | CHRM2 (0.32) | CHRM2CHRM1GAALMNASMN1; SMN2 | |
| SCHEMBL7438903 | 0.77 | MAOA (0.40) | THRBTHRAALDH1A1CA2CHRM2 | |
| SCHEMBL7437442 | 0.75 | TSHR (0.45) | CHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL7282803 | 0.74 | THRB (0.42) | THRBTHRAMMP1ALDH1A1CA2 | |
| SCHEMBL7434817 | 0.73 | LMNA (0.51) | ALDH1A1CYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL7426489 | 0.73 | CHRM2 (0.38) | ALDH1A1CA2CHRM2CHRM1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |