Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445601 | 0.78 | DRD2 (0.42) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL8311336 | 0.74 | HTR2A (0.43) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL8317710 | 0.72 | VCAM1 (0.37) | HTR1ADRD2ALDH1A1 | |
| SCHEMBL7447925 | 0.72 | ALDH1A1 (0.40) | HTR1AHTR7DRD2DRD3ALDH1A1 | |
| SCHEMBL8631076 | 0.71 | DRD2 (0.36) | HTR1ADRD2CYP1A2CYP2D6TSHR | |
| SCHEMBL8633421 | 0.71 | HTR1A (0.51) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL8312041 | 0.71 | HTR1A (0.51) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL13434155 | 0.69 | ADH1A (0.43) | DRD2DRD3CYP1A2 | |
| SCHEMBL9755468 | 0.69 | HTR1D (0.66) | HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL8845620 | 0.69 | FYN (0.38) | HTR1ADRD2DRD3CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516383-B1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2017-05-03 | — | — | EP | disclosed |
| US-8586603-B2 | Aminotetraline derivatives | GMEINER PETER (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20120277262-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2012-11-01 | — | — | US | disclosed |
| US-20120277262-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2012-11-01 | — | — | US | disclosed |
| WO-2011076708-A1 | NEW AMINOTETRALINE DERIVATIVES | GMEINER PETER (DE) | 2011-06-30 | — | — | WO | disclosed |
| EP-2338873-A1 | New aminotetraline derivatives | Gmeiner, Peter (DE) | 2011-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277262-A1 | NEW AMINOTETRALINE DERIVATIVES | AADAT, ABAT, AANAT | HTR1A 159/4885HTR7 119/4885DRD2 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.