Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | TDP2 | O95551 | 1/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | GALK1 | P51570 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478083 | 0.85 | MAPT (0.47) | KMT2AMAPTKDM4EAPAF1TDP2 | |
| SCHEMBL7471334 | 0.84 | SMN1; SMN2 (0.52) | KMT2AMAPTMEN1RAB9ANPC1 | |
| SCHEMBL7483158 | 0.84 | MMP9 (0.41) | KMT2AMAPTKDM4EMEN1RAB9A | |
| SCHEMBL7482004 | 0.83 | ALDH1A1 (0.46) | KMT2AMAPTKDM4EAPAF1TDP2 | |
| SCHEMBL7479933 | 0.81 | ALDH1A1 (0.51) | KMT2AMAPTKDM4ESENP7MEN1 | |
| SCHEMBL7480698 | 0.81 | AKR1B1 (0.48) | KMT2AMAPTKDM4EAPAF1TDP2 | |
| SCHEMBL7472363 | 0.80 | L3MBTL1 (0.49) | KMT2AMAPTKDM4EAPAF1TDP2 | |
| SCHEMBL7477845 | 0.80 | MMP9 (0.42) | KMT2AMAPTKDM4EAPAF1TDP2 | |
| SCHEMBL7474643 | 0.80 | ALDH1A1 (0.45) | KMT2AMAPTKDM4ESENP8SENP7 | |
| SCHEMBL7475641 | 0.80 | PTGS2 (0.44) | KMT2AMAPTKDM4ECES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |