Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482004 | 0.91 | ALDH1A1 (0.46) | AKR1B1MMP9MMP2MEN1KMT2A | |
| SCHEMBL7477845 | 0.87 | MMP9 (0.42) | MMP9MMP2MEN1KMT2AADAM17 | |
| SCHEMBL7478795 | 0.87 | LMNA (0.45) | MMP9MMP2MEN1KMT2ACES2 | |
| SCHEMBL7474643 | 0.87 | ALDH1A1 (0.45) | MMP9MMP2MEN1KMT2ANPC1 | |
| SCHEMBL7475641 | 0.87 | PTGS2 (0.44) | MMP9MMP2MEN1KMT2ACES2 | |
| SCHEMBL7470955 | 0.84 | HTT (0.46) | MEN1KMT2AGAARAB9AHTT | |
| SCHEMBL7475491 | 0.83 | PLK1 (0.45) | MMP9MMP2GAANPC1RAB9A | |
| SCHEMBL7478759 | 0.83 | MMP2 (0.43) | MMP9MMP2MEN1KMT2ANPC1 | |
| SCHEMBL7482164 | 0.83 | MMP2 (0.49) | CNR2MMP9MMP2KMT2ACES2 | |
| SCHEMBL7484780 | 0.83 | MMP9 (0.46) | MMP9MMP2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |