Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7643613 | 0.87 | CA1 (0.52) | ALDH1A1GAA | |
| SCHEMBL7475852 | 0.85 | KMT2A (0.53) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL7474409 | 0.81 | MAOA (0.54) | MAPTKMT2AMEN1GAASAE1 | |
| SCHEMBL7478795 | 0.78 | LMNA (0.45) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7471334 | 0.77 | SMN1; SMN2 (0.52) | MAPTTP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL7483158 | 0.77 | MMP9 (0.41) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL7482004 | 0.76 | ALDH1A1 (0.46) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL7477845 | 0.76 | MMP9 (0.42) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL7483118 | 0.74 | NR1H4 (0.44) | TP53KMT2AMEN1LMNAMMP9 | |
| SCHEMBL7479933 | 0.74 | ALDH1A1 (0.51) | MAPTCNR2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |