Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477823 | 0.88 | MAPT (0.42) | ALDH1A1GAAMAPTPKMHPGD | |
| SCHEMBL7483466 | 0.88 | SLC6A5 (0.48) | GAAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7482164 | 0.84 | MMP2 (0.49) | ALDH1A1GAACNR2KMT2ANPC1 | |
| SCHEMBL7480996 | 0.83 | RAB9A (0.56) | ALDH1A1MAPTCNR2MEN1KMT2A | |
| SCHEMBL7475852 | 0.81 | KMT2A (0.53) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL7646518 | 0.80 | NR1H4 (0.43) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL7478795 | 0.79 | LMNA (0.45) | ALDH1A1GAAMAPTMEN1KMT2A | |
| SCHEMBL7477845 | 0.79 | MMP9 (0.42) | ALDH1A1MAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL7482416 | 0.78 | MEN1 (0.58) | ALDH1A1MAPTPKMHPGDALOX12 | |
| SCHEMBL7482423 | 0.78 | MEN1 (0.58) | ALDH1A1MAPTPKMHPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |