Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 16/20 | 0.48 |
| ▸ | CA1 | P00915 | 12/20 | 0.48 |
| ▸ | CA9 | Q16790 | 7/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482004 | 0.85 | ALDH1A1 (0.46) | CA1CA9CA12MEN1MAPT | |
| SCHEMBL7477845 | 0.84 | MMP9 (0.42) | MEN1POLBMAPTRECQLKMT2A | |
| SCHEMBL7475641 | 0.81 | PTGS2 (0.44) | MEN1POLBMAPTKMT2AGAA | |
| SCHEMBL7474643 | 0.81 | ALDH1A1 (0.45) | MEN1POLBMAPTKMT2A | |
| SCHEMBL7478795 | 0.81 | LMNA (0.45) | MEN1POLBMAPTKMT2AGAA | |
| SCHEMBL7643613 | 0.81 | CA1 (0.52) | CA2CA1CA9CA12GAA | |
| SCHEMBL7478083 | 0.81 | MAPT (0.47) | MEN1MAPTKMT2ASAE1UBA2 | |
| SCHEMBL7470955 | 0.79 | HTT (0.46) | CA1CA9MEN1KMT2AGAA | |
| SCHEMBL7478759 | 0.78 | MMP2 (0.43) | MEN1MAPTKMT2A | |
| SCHEMBL7475491 | 0.78 | PLK1 (0.45) | POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |