Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482004 | 0.90 | ALDH1A1 (0.46) | LMNAMAPTMMP9MMP2MMP8 | |
| SCHEMBL7483158 | 0.87 | MMP9 (0.41) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7480698 | 0.87 | AKR1B1 (0.48) | LMNAPOLBNPC1RAB9AMAPT | |
| SCHEMBL7474643 | 0.86 | ALDH1A1 (0.45) | LMNAPOLBNPC1RAB9AMAPT | |
| SCHEMBL7477845 | 0.86 | MMP9 (0.42) | POLBMAPTMMP9MMP2MMP8 | |
| SCHEMBL7475641 | 0.86 | PTGS2 (0.44) | LMNAPOLBNPC1RAB9AMAPT | |
| SCHEMBL7475491 | 0.85 | PLK1 (0.45) | POLBNPC1RAB9AMMP9MMP2 | |
| SCHEMBL7482164 | 0.85 | MMP2 (0.49) | NPC1RAB9ASMN1; SMN2MMP9MMP2 | |
| SCHEMBL7475852 | 0.85 | KMT2A (0.53) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7471334 | 0.85 | SMN1; SMN2 (0.52) | POLBNPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |