Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481304 | 0.86 | NPC1 (0.49) | ALDH1A1SMN1; SMN2KDM4EGAAKMT2A | |
| SCHEMBL7480996 | 0.86 | RAB9A (0.56) | CNR2ALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL7482004 | 0.86 | ALDH1A1 (0.46) | MMP2MMP9MMP8ALDH1A1KDM4E | |
| SCHEMBL7478795 | 0.85 | LMNA (0.45) | MMP2MMP9MMP8ALDH1A1SMN1; SMN2 | |
| SCHEMBL7479933 | 0.84 | ALDH1A1 (0.51) | CNR2ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL7480698 | 0.83 | AKR1B1 (0.48) | MMP2MMP9MMP8CNR2ALDH1A1 | |
| SCHEMBL7474643 | 0.82 | ALDH1A1 (0.45) | MMP2MMP9ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7475641 | 0.82 | PTGS2 (0.44) | MMP2MMP9MMP8ALDH1A1KDM4E | |
| SCHEMBL7477845 | 0.82 | MMP9 (0.42) | MMP2MMP9MMP8ALDH1A1KDM4E | |
| SCHEMBL7479732 | 0.82 | RAB9A (0.51) | ALDH1A1SMN1; SMN2KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |