Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 6/20 | 0.44 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.43 |
| ▸ | CA4 known ✓ | P22748 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL1436676 | 1.00 | — | — | |
| Alanine SCHEMBL735033 | 1.00 | — | — | |
| Alanine SCHEMBL5943276 | 0.93 | SLC7A5 (0.38) | CA1CA2CYP3A4TSHRNFKB1 | |
| Alanine SCHEMBL7614895 | 0.93 | SLC7A5 (0.38) | CA1CA2CYP3A4TSHRNFKB1 | |
| Alanine SCHEMBL10814860 | 0.93 | SLC7A5 (0.38) | CA1CA2CYP3A4TSHRNFKB1 | |
| Alanine SCHEMBL19326825 | 0.93 | SLC7A5 (0.38) | CA1CA2CYP3A4TSHRNFKB1 | |
| Alanine SCHEMBL7616260 | 0.93 | SLC7A5 (0.38) | CA1CA2CYP3A4TSHRNFKB1 | |
| Alanine SCHEMBL4669777 | 0.93 | — | — | |
| Alanine SCHEMBL497114 | 0.93 | SLC7A5 (0.38) | CA1CA2CYP3A4TSHRNFKB1 | |
| Alanine SCHEMBL18301600 | 0.93 | GABRP (0.39) | CA1CA2CYP3A4TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4073080-B1 | PROCESS FOR INDUSTRIAL PREPARATION OF THE DISODIUM SALT OF ((2S)-3-([1,1'-BIPHENYL]-4-YL)-2-((HYDROXY((1R)-1-(((1-(ISOBUTYRYLOXY)ETHOXY)CARBONYL)AMINO)ETHYL)PHOSPHORYL)METHYL)PROPANOYL)-L-ALANINE | KOS THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | claimed |
| CN-105814014-B | Novel gemini surfactants and their use | 英派尔科技开发有限公司 | 2018-06-12 | — | — | CN | disclosed |
| CN-101325946-B | Hair treatment compositions | AVON PROD INC | 2013-06-12 | — | — | CN | disclosed |
| CN-101325946-A | Novel hair treatment compositions | AVON PROD INC (US) | 2008-12-17 | — | — | CN | disclosed |
| EP-1213611-A2 | Photographic element and package | EASTMAN KODAK COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1182500-A2 | Improved color negative film | EASTMAN KODAK COMPANY (US) | 2002-02-27 | — | — | EP | disclosed |