Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19900387 | 0.83 | PTGS1 (0.72) | PTGS1MEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL6860378 | 0.81 | PTGS1 (0.69) | PTGS1MEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL5080304 | 0.80 | PTGS2 (0.56) | PTGS1LMNAPTGS2ALOX5 | |
| SCHEMBL11570387 | 0.80 | PTGS2 (0.56) | PTGS1LMNAPTGS2ALOX5 | |
| SCHEMBL891511 | 0.79 | PTGS1 (0.71) | PTGS1MEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL13879183 | 0.79 | PSMB5 (0.47) | PTGS1ALDH1A1LMNAPTGS2ALOX5 | |
| SCHEMBL14217614 | 0.79 | KDM4E (0.56) | ALDH1A1KDM4ESMN1; SMN2PTGS2 | |
| SCHEMBL2556525 | 0.78 | PTGS1 (0.76) | PTGS1MEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL30464902 | 0.78 | PTGS1 (0.76) | PTGS1MEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL6861607 | 0.78 | PTGS1 (0.76) | PTGS1MEN1KMT2ACYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100588644-C | Eugenol ibuprofen ester medical compound and its preparation and preparation method | UNIV SHENYANG PHARMACEUTICAL | 2010-02-10 | — | — | CN | claimed |
| CN-1597656-A | Eugenol ibuprofen ester medical compound and its preparation and preparation method | SHENYONG PHARMACEUTICAL UNIVER (CN) | 2005-03-23 | — | — | CN | claimed |
| EP-3178822-B1 | PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF | FU LI (CN) | 2019-03-13 | — | — | EP | disclosed |
| US-9963461-B2 | Phillygenin ibuprofen ester, preparation method therefor, and application thereof | FU LI (CN) | 2018-05-08 | — | — | US | disclosed |
| US-20170233403-A1 | PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | FU LI (CN) | 2017-08-17 | — | — | US | disclosed |
| EP-3178822-A1 | PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF | Fu, Li (CN) | 2017-06-14 | — | — | EP | disclosed |
| CN-103003228-B | Compounds based on ibuprofen, preparation methods, uses and pharmaceutical preparation thereof | HOU WENGE | 2015-03-25 | — | — | CN | disclosed |
| US-20140112978-A1 | IBUPROFEN-BASED COMPOUND, PREPARATION METHOD, USE, AND FORMULATION OF THE SAME | Hellongjoamg Baoqinglong Biotechnology Co. Ltd. (VN) | 2014-04-24 | — | — | US | disclosed |
| US-8703975-B2 | Aryl (ethanoic) propanoic acid ascorbyl ester, preparation method thereof and medicament containing the same | WUXI HONGRUI BIO-PHARMA-TECH CO., LTD. (CN) | 2014-04-22 | — | — | US | disclosed |
| CN-103003228-A | Compounds based on ibuprofen, preparation methods, uses and pharmaceutical preparation thereof | HEILONGJIANG BAOQINGLONG BIOTECHNOLOGY CO LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-102085205-B | Medical compound preparation of eugenol aspirin ester and method for preparing same | LANZHOU INST ANIMAL SCIENCE & VETERINARY PHARMACEUTICS CAAS | 2012-08-29 | — | — | CN | disclosed |
| CN-101550119-B | Ascorbic esters of aryl (ethyl) propionic acids, process for their preparation and medicaments containing them | WUXI HONGRUI BIOMEDICINE TECHNOLOGY CO LTD | 2012-05-30 | — | — | CN | disclosed |
| US-20120115897-A1 | Aryl (Ethanoic) Propanoic Acid Ascorbyl Ester, Preparation Method Thereof And Medicament Containing The Same | WUXI HONGRUI BIO-PHARMA-TECH CO., LTD . (CN) | 2012-05-10 | — | — | US | disclosed |
| EP-2431361-A1 | ASCORBIC ACID ARYL ACETATE/PROPIONATE ESTER, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | Wuxi Hongrui Biomedical Technology Co., Ltd. (CN) | 2012-03-21 | — | — | EP | disclosed |
| CN-102085205-A | Medical compound preparation of eugenol aspirin ester and method for preparing same | LANZHOU VETERINARY RES INST CHINESE ACADEMY OF AGRICULTURE SCEENCES | 2011-06-08 | — | — | CN | disclosed |
| CN-101270052-B | Eugenol aspirin ester medicinal compound and its preparation and preparation method | LANZHOU INST OF ANIMAL SCIENCE AND VETERINARY PHARMACEUTICS CAAS | 2010-06-09 | — | — | CN | disclosed |
| CN-100588644-C | Eugenol ibuprofen ester medical compound and its preparation and preparation method | UNIV SHENYANG PHARMACEUTICAL | 2010-02-10 | — | — | CN | disclosed |
| CN-101550119-A | Aryl (ethanoic) propanoic acid ascorbyl ester, preparation method thereof and medicament containing same | UNIV JIANGNAN (CN) | 2009-10-07 | — | — | CN | disclosed |
| CN-101270052-A | Eugenol aspirin ester medicinal compound and its preparation and preparation method | LANZHOU INST OF ANIMAL SCIENCE (CN) | 2008-09-24 | — | — | CN | disclosed |
| CN-1597656-A | Eugenol ibuprofen ester medical compound and its preparation and preparation method | SHENYONG PHARMACEUTICAL UNIVER (CN) | 2005-03-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233403-A1 | PHILLYGENIN IBUPROFEN ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | CYP4F11, COX15, PTGS1 | PTGS1 3/4885MEN1 3747/4885KMT2A 3777/4885 |
| US-20120115897-A1 | Aryl (Ethanoic) Propanoic Acid Ascorbyl Ester, Preparation Method Thereof And Medicament Containing The Same | HTRA2, CYP27A1, ALOX15 | PTGS1 31/4885MEN1 4002/4885KMT2A 4293/4885 |
| US-20140112978-A1 | IBUPROFEN-BASED COMPOUND, PREPARATION METHOD, USE, AND FORMULATION OF THE SAME | FABP4, ELOVL6, ALOX5 | PTGS1 16/4885MEN1 3475/4885KMT2A 4425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.