SCHEMBL7543196

SCHEMBL7543196

CN1CCN(c2ccc(C(=O)[O-])cn2)CC1.[Na+]

nearest known ligand 0.55

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.52
ALDH1A1 P00352 2/20 0.49
KDM4E B2RXH2 2/20 0.49
KMT2A Q03164 2/20 0.49
NPC1 O15118 1/20 0.49
HDAC2 Q92769 4/20 0.48
HDAC3 O15379 4/20 0.48
HDAC10 Q969S8 2/20 0.46
DYRK1A Q13627 2/20 0.45
WNT1 P04628 1/20 0.45
CLK2 P49760 1/20 0.45
CLK3 P49761 1/20 0.45
GSK3B P49841 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21776925 0.86 RAB9A (0.59) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL30665072 0.84 RAB9A (0.58) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL1329870 0.84 RAB9A (0.58) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL6117108 0.84 RAB9A (0.58) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL7530613 0.84 HRH3 (0.54) RAB9AKMT2ANPC1
SCHEMBL7525198 0.84 KDM4E (0.54) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL4460927 0.83 RAB9A (0.56) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL19160081 0.83 RAB9A (0.59) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL5009801 0.82 RAB9A (0.55) RAB9AL3MBTL1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL7550035 0.82 HPGDS (0.49) RAB9AALDH1A1KDM4EKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885886-B1 PYRIDINECARBOXAMIDE DERIVATIVES NISSHIN SEIFUN GROUP INC (JP) 2002-05-29 EP disclosed
US-5972943-A N-(NITRIC ACID,C14-18 ALKYL ESTER)-6-(1-(OPTIONALLY 4-SUBSTITUTED PIPERAZINYL)) PYRIDINE-3-CARBOXAMIDES; METHOD OF SYNTHESIS; ADMINISTERING TO TREAT CEREBRAL EDEMA; NO HYPOTENSIVE SIDE EFFECT NISSHIN FLOUR MILLING CO., LTD. (JP) 1999-10-26 US disclosed
EP-0885886-A1 NOVEL PYRIDINECARBOXAMIDE DERIVATIVES Nisshin Flour Milling Co., Ltd. (JP) 1998-12-23 EP disclosed