SCHEMBL7544299

SCHEMBL7544299

C=C(C#N)C(=O)NCc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 2/20 0.60
LMNA P02545 2/20 0.59
PLIN1 O60240 1/20 0.59
PLIN5 Q00G26 1/20 0.59
ABHD5 Q8WTS1 1/20 0.59
HPGD P15428 4/20 0.56
GLA P06280 1/20 0.55
MEN1 O00255 5/20 0.54
KMT2A Q03164 5/20 0.54
MAPT P10636 4/20 0.50
ALDH1A1 P00352 4/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
RAB9A P51151 2/20 0.50
EEF2K O00418 1/20 0.50
PLK4 O00444 1/20 0.50
PIM1 P11309 1/20 0.50
AXL P30530 1/20 0.50
MAPKAPK2 P49137 1/20 0.50
GSK3A P49840 1/20 0.50
GSK3B P49841 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12220311 0.83 PLAAT5 (0.57) HPGDMEN1KMT2AMAPTALDH1A1
SCHEMBL8517079 0.80 ALDH1A1 (0.58) LMNAHPGDMEN1KMT2AMAPT
SCHEMBL3056874 0.79 KMT2A (0.71) LMNAHPGDMEN1KMT2AMAPT
SCHEMBL5698188 0.79 TXNRD1 (0.54) LMNAPLIN1PLIN5ABHD5HPGD
SCHEMBL5175379 0.79 TXNRD1 (0.54) LMNAPLIN1PLIN5ABHD5HPGD
SCHEMBL16628771 0.78 ALDH1A1 (0.56) LMNAPLIN1PLIN5ABHD5HPGD
SCHEMBL653442 0.78 MCL1 (0.62) MCL1LMNAPLIN1PLIN5ABHD5
SCHEMBL23942226 0.78 LMNA (0.75) MCL1LMNAPLIN1PLIN5ABHD5
SCHEMBL24584925 0.77 TXNRD1 (0.52) LMNAPLIN1PLIN5ABHD5HPGD
SCHEMBL553682 0.77 TXNRD1 (0.56) LMNAPLIN1PLIN5ABHD5HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020065314-A1 COMPOSITIONS AND METHOD FOR STIMULATING HAIR GROWTH S.N. BIOTECH, INC. 2002-05-30 US claimed
US-20020065314-A1 COMPOSITIONS AND METHOD FOR STIMULATING HAIR GROWTH S.N. BIOTECH, INC. 2002-05-30 US disclosed
EP-0824316-A4 COMPOSITIONS AND METHODS FOR STIMULATING HAIR GROWTH NIELSEN THOR B (US) 2001-01-17 EP disclosed
US-5767152-A USING A CYANOCARBOXYLIC ACID S.N. BIOTECH, INC. 1998-06-16 US disclosed
EP-0824316-A1 COMPOSITIONS AND METHODS FOR STIMULATING HAIR GROWTH Nielsen, Thor, B. (US) 1998-02-25 EP disclosed
WO-1996034526-A1 COMPOSITIONS AND METHODS FOR STIMULATING HAIR GROWTH NIELSEN THOR B (US) 1996-11-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020065314-A1 COMPOSITIONS AND METHOD FOR STIMULATING HAIR GROWTH AREG, NGF, HDGF MCL1 1408/4885LMNA 3582/4885PLIN1 822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.