SCHEMBL7545108

SCHEMBL7545108

COC(=O)CCCCCCCCCCCCCCCN

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.64
PAOX Q6QHF9 4/20 0.56
LMNA P02545 4/20 0.55
ALDH1A1 P00352 2/20 0.55
KMT2A Q03164 2/20 0.52
RECQL P46063 2/20 0.52
MEN1 O00255 1/20 0.52
PLG P00747 1/20 0.52
THRB P10828 1/20 0.52
ALOX15 P16050 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A3 Q01959 1/20 0.52
KDM4E B2RXH2 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.48
NFKB1 P19838 1/20 0.48
BLM P54132 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1147174 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL7545025 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL1235539 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL1701715 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL3208419 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL2822938 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL7541388 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL7548607 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL2128896 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A
SCHEMBL905418 1.00 TSHR (0.64) TSHRPAOXLMNAALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12595495-B2 Methods of producing omega-hydroxylated fatty acid derivatives GENOMATICA, INC. (US) 2026-04-07 US disclosed
US-20250019731-A1 Methods Of Producing Omega-Hydroxylated Fatty Acid Derivatives AGAIN BIO APS (DK) 2025-01-16 US disclosed
US-11981952-B2 Methods of producing omega-hydroxylated fatty acid derivatives GENOMATICA, INC. (US) 2024-05-14 US disclosed
US-11912997-B2 RNAi agents for inhibiting expression of Superoxide Dismutase 1 (SOD1), compositions thereof, and methods of use Arrowhead Pharmaceuticals, Inc. (US) 2024-02-27 US disclosed
US-20210071212-A1 METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES GENOMATICA, INC. (US) 2021-03-11 US disclosed
EP-3745133-A1 METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES Genomatica, Inc. (US) 2020-12-02 EP disclosed
US-10711288-B2 Methods of producing omega-hydroxylated fatty acid derivatives GENOMATICA, INC. (US) 2020-07-14 US disclosed
EP-3673921-A1 MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN Baxalta GmbH (CH) 2020-07-01 EP disclosed
EP-2984490-B1 METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES GENOMATICA INC (US) 2020-05-20 EP disclosed
EP-2654794-B1 MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN Baxalta GmbH (CH) 2020-03-04 EP disclosed
EP-2984490-A1 METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES REG Life Sciences, LLC (US) 2016-02-17 EP disclosed
US-8945897-B2 Materials and methods for conjugating a water soluble fatty acid derivative to a protein BAXTER INTERNATIONAL INC. (US) 2015-02-03 US disclosed
WO-2014201474-A1 METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES LS9, INC. (US) 2014-12-18 WO disclosed
EP-2654794-A1 MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN Baxter International Inc (US) 2013-10-30 EP disclosed
US-20120190096-A1 MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN BAXTER HEALTHCARE S.A. (CH) 2012-07-26 US disclosed
WO-2012087838-A1 MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN BAXTER INTERNATIONAL INC. (US) 2012-06-28 WO disclosed
EP-0885886-B1 PYRIDINECARBOXAMIDE DERIVATIVES NISSHIN SEIFUN GROUP INC (JP) 2002-05-29 EP disclosed
US-5972943-A N-(NITRIC ACID,C14-18 ALKYL ESTER)-6-(1-(OPTIONALLY 4-SUBSTITUTED PIPERAZINYL)) PYRIDINE-3-CARBOXAMIDES; METHOD OF SYNTHESIS; ADMINISTERING TO TREAT CEREBRAL EDEMA; NO HYPOTENSIVE SIDE EFFECT NISSHIN FLOUR MILLING CO., LTD. (JP) 1999-10-26 US disclosed
EP-0885886-A1 NOVEL PYRIDINECARBOXAMIDE DERIVATIVES Nisshin Flour Milling Co., Ltd. (JP) 1998-12-23 EP disclosed
US-5468888-A Lupane derivatives, their preparation and the pharmaceutical compositions which contain them RHONE-POULENC RORER S.A. (FR) 1995-11-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11912997-B2 RNAi agents for inhibiting expression of Superoxide Dismutase 1 (SOD1), compositions thereof, and methods of use SOD1, SOD3, SMN1; SMN2 TSHR 4636/4885PAOX 2489/4885LMNA 2101/4885
US-12595495-B2 Methods of producing omega-hydroxylated fatty acid derivatives CYP4F11, CYP2F1, CYP4Z1 TSHR 1330/4885PAOX 684/4885LMNA 3439/4885
US-20120190096-A1 MATERIALS AND METHODS FOR CONJUGATING A WATER SOLUBLE FATTY ACID DERIVATIVE TO A PROTEIN FABP1, FABP4, FABP5 TSHR 3304/4885PAOX 498/4885LMNA 2670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.