SCHEMBL755484

SCHEMBL755484

CC(=O)[C@@H](N)CCC(=O)O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.65
GRM8 O00222 1/20 0.65
GRM6 O15303 1/20 0.65
GRIN2D O15399 1/20 0.65
GRIN3B O60391 1/20 0.65
GSR P00390 1/20 0.65
GRIK1 P39086 1/20 0.65
GRM5 P41594 1/20 0.65
GRIA1 P42261 1/20 0.65
GRIA2 P42262 1/20 0.65
GRIA3 P42263 1/20 0.65
SLC1A3 P43003 1/20 0.65
SLC1A2 P43004 1/20 0.65
SLC1A1 P43005 1/20 0.65
GRIA4 P48058 1/20 0.65
GRIN1 Q05586 1/20 0.65
GRIN2A Q12879 1/20 0.65
GRIK2 Q13002 1/20 0.65
GRIK3 Q13003 1/20 0.65
GRIN2B Q13224 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5813285 1.00 CYP1A2 (0.65) CYP1A2GRM8GRM6GRIN2DGRIN3B
SCHEMBL17830393 1.00 CYP1A2 (0.65) CYP1A2GRM8GRM6GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL4936629 0.98 CYP1A2 (0.62) CYP1A2GRM8GRM6GRIN2DGRIN3B
SCHEMBL23897855 0.86 ENPEP (0.52) CYP1A2GRM8GRM6GRIN2DGRIN3B
SCHEMBL27675061 0.86 ENPEP (0.52) CYP1A2GRM8GRM6GRIN2DGRIN3B
SCHEMBL11795885 0.84 ALDH1A1 (0.55) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL15797537 0.83 GRM8 (0.86) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL184512 0.83 GRM8 (0.86) CYP1A2GRM8GRM6GRIN2DGRIN3B
Glutamic Acid SCHEMBL2803034 0.83 GRM8 (0.86) CYP1A2GRM8GRM6GRIN2DGRIN3B
Glutamic Acid SCHEMBL184513 0.83 GRM8 (0.86) CYP1A2GRM8GRM6GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024114953-A1 PHYLLOCHLORIN ANALOGUES SUITABLE FOR USE IN PHOTODYNAMIC THERAPY (PDT) RMW CHO GROUP LIMITED (CN) 2024-06-06 WO disclosed
US-20240067702-A1 LACTAM-MODIFIED POLYPEPTIDE COMPOUNDS TONGHUA DONGBAO PHARMACEUTICAL CO., LTD. (CN) 2024-02-29 US disclosed
US-20240016946-A1 DRUG-LOADED MACROMOLECULE AND PREPARATION METHOD THEREFOR SHANGHAI SHENGDI PHARMACEUTICAL CO., LTD. (CN) 2024-01-18 US disclosed
US-20230364248-A1 MIC-1 COMPOUNDS AND USES THEREOF NOVO NORDISK AS (DK) 2023-11-16 US disclosed
US-11814444-B2 Cyclic polypeptides for PCSK9 inhibition RA PHARMACEUTICALS, INC. (US) 2023-11-14 US disclosed
WO-2023137026-A1 CAMPTOTHECIN ANALOGS CONJUGATED TO A GLUTAMINE RESIDUE IN A PROTEIN, AND THEIR USE REGENERON PHARMACEUTICALS, INC. (US) 2023-07-20 WO disclosed
WO-2023094677-A1 PHOTODYNAMIC THERAPY AND DIAGNOSIS RMW CHO GROUP LIMITED (CN) 2023-06-01 WO disclosed
US-20230144845-A1 Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth UNIV CALIFORNIA (US) 2023-05-11 US disclosed
WO-2022174179-A9 4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO EMORY UNIVERSITY (US) 2023-02-02 WO disclosed
US-11541049-B2 Tetrahydroisoquinoline derivatives, preparation process and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2023-01-03 US disclosed
US-20100081786-A1 Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-01 US disclosed
US-20100081786-A1 Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-01 US disclosed
US-20100029636-A1 Lck inhibitors NOVARTIS AG (CH) 2010-02-04 US disclosed
US-20100029636-A1 Lck inhibitors NOVARTIS AG (CH) 2010-02-04 US disclosed
WO-2009141619-A1 METHODS OF DISTINGUISHING BETWEEN GLUTAMINE FORMED BY CATAPLEROSIS OR PROTEOLYSIS Biocant - Associação De Transferência De Tecnologia (PT) 2009-11-26 WO disclosed
US-20090270457-A1 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. 2009-10-29 US disclosed
US-20090264380-A1 6,11-BRIDGED BIARYL MACROLIDES ENANTA PHARMACEUTICALS, INC. 2009-10-22 US disclosed
US-20090075915-A1 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES ENANTA PHARMACEUTICALS, INC. 2009-03-19 US disclosed
EP-0688314-A1 PRODRUG DERIVATIVES OF ENZYME INHIBITORS WITH HYDROXYL GROUPS, METHODS OF PREPARING THEM AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1995-12-27 EP disclosed
WO-1994021604-A1 PRODRUG DERIVATIVES OF ENZYME INHIBITORS WITH HYDROXYL GROUPS, METHODS OF PREPARING THEM AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1994-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090075915-A1 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES CYP2B6, ABCB11, CYP2D6 CYP1A2 50/4885GRM8 4559/4885GRM6 3715/4885
US-20090270457-A1 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES CYP2B6, ABCB11, CYP2D6 CYP1A2 50/4885GRM8 4559/4885GRM6 3715/4885
US-20230364248-A1 MIC-1 COMPOUNDS AND USES THEREOF IMMT, MICA, TAP1 CYP1A2 3232/4885GRM8 3875/4885GRM6 4206/4885
US-20230144845-A1 Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth HOGA1, GCDH, LDHB CYP1A2 2055/4885GRM8 2273/4885GRM6 2004/4885
US-20100081786-A1 Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation EPOR, LIFR, LNPEP CYP1A2 3921/4885GRM8 4443/4885GRM6 3431/4885
US-20240067702-A1 LACTAM-MODIFIED POLYPEPTIDE COMPOUNDS PTMS, PEPD, VIP CYP1A2 2464/4885GRM8 2012/4885GRM6 1678/4885
US-11814444-B2 Cyclic polypeptides for PCSK9 inhibition PCSK9, LDLR, PCSK7 CYP1A2 4606/4885GRM8 3786/4885GRM6 4218/4885
US-11541049-B2 Tetrahydroisoquinoline derivatives, preparation process and use thereof CYP3A4, CYP3A43, CYP11B2 CYP1A2 12/4885GRM8 4079/4885GRM6 4663/4885
US-20240016946-A1 DRUG-LOADED MACROMOLECULE AND PREPARATION METHOD THEREFOR MRPL38, MRPS27, MRPS18A CYP1A2 2683/4885GRM8 229/4885GRM6 706/4885
US-20090264380-A1 6,11-BRIDGED BIARYL MACROLIDES CYP2B6, CYP2D6, ABCB11 CYP1A2 27/4885GRM8 4676/4885GRM6 3316/4885
US-20100029636-A1 Lck inhibitors LCK, ZAP70, FYN CYP1A2 3961/4885GRM8 3528/4885GRM6 3224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.