Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467199 | 0.89 | DAGLA (0.41) | DAGLACES1LMNAPKMNAPEPLD | |
| SCHEMBL6461813 | 0.84 | P2RX7 (0.40) | DAGLA | |
| SCHEMBL6467926 | 0.83 | DAGLA (0.44) | DAGLACES1LMNAPKMKMT2A | |
| SCHEMBL7558531 | 0.81 | DAGLA (0.39) | DAGLALMNAPKMFAAHKMT2A | |
| SCHEMBL6461816 | 0.81 | DAGLA (0.42) | DAGLACES1 | |
| SCHEMBL7044843 | 0.78 | L3MBTL1 (0.39) | DAGLALMNA | |
| SCHEMBL7047979 | 0.78 | TBXA2R (0.41) | DAGLALMNA | |
| SCHEMBL6475520 | 0.77 | DAGLA (0.50) | DAGLACES1FAAH | |
| SCHEMBL7186571 | 0.76 | MASP2 (0.38) | DAGLALMNAKMT2A | |
| SCHEMBL7047180 | 0.75 | P2RX7 (0.37) | DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |