Sugi Predict

Sugi Predict / Compounds / SCHEMBL757286

SCHEMBL757286

SCHEMBL757286

CCOC(=O)c1ccn(C)c(=O)c1OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.46
▸ KDM4E B2RXH2 7/20 0.45
▸ ALDH1A1 P00352 6/20 0.45
▸ GAA P10253 5/20 0.45
▸ HPGD P15428 4/20 0.45
▸ GLA P06280 3/20 0.45
▸ BAZ2B Q9UIF8 1/20 0.44
▸ BAZ2A Q9UIF9 1/20 0.44
▸ HSD17B10 Q99714 3/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.42
▸ RXFP1 Q9HBX9 1/20 0.42
▸ MAPT P10636 4/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ RECQL P46063 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ CA12 O43570 2/20 0.40
▸ CA1 P00915 2/20 0.40
▸ CA2 P00918 2/20 0.40
▸ CA7 P43166 2/20 0.40
▸ CA9 Q16790 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16925518 0.81 TSHR (0.49) TSHRKDM4EALDH1A1GAAHPGD
SCHEMBL17848969 0.80 KDM4E (0.47) TSHRKDM4EALDH1A1GAAHPGD
SCHEMBL14829178 0.79 MAPT (0.46) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL14848164 0.78 KDM4E (0.40) TSHRKDM4EALDH1A1GAAHPGD
SCHEMBL3431214 0.78 BRD4 (0.36) TSHRKDM4EALDH1A1HPGDHSD17B10
SCHEMBL14829175 0.78 MAPT (0.39) KDM4EALDH1A1GAAHSD17B10MAPT
SCHEMBL2888240 0.77 TSHR (0.55) TSHRKDM4EALDH1A1GAAHPGD
SCHEMBL755373 0.77 CTSD (0.45) KDM4EALDH1A1GAAMAPTSMN1; SMN2
Hydrazine SCHEMBL3431213 0.76 MAPT (0.44) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL3444338 0.76 KDM4E (0.49) TSHRKDM4EALDH1A1GAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220143229-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-05-12 — — US disclosed
US-20220143229-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-05-12 — — US disclosed
US-11260136-B2 Radio-pharmaceutical complexes BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-03-01 — — US disclosed
US-20210322583-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER AS (NO) 2021-10-21 — — US disclosed
US-20210322583-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER AS (NO) 2021-10-21 — — US disclosed
CN-107278155-B Radiopharmaceutical complexes 拜耳有限公司 2021-03-30 — — CN disclosed
US-20190298865-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-10-03 — — US disclosed
US-20190298865-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-10-03 — — US disclosed
EP-3468619-A1 RADIO-PHARMACEUTICAL COMPLEXES Bayer Pharma Aktiengesellschaft (DE) 2019-04-17 — — EP disclosed
US-20190091354-A1 RADIO-PHARMACEUTICAL COMPLEXES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-03-28 — — US disclosed
US-20140235608-A1 PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-21 — — US disclosed
US-20140235608-A1 PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-21 — — US disclosed
WO-2013049104-A1 PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE BRISTOL-MYERS SQUIBB COMPANY (US) 2013-04-04 — — WO disclosed
WO-2013048930-A1 PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE BRISTOL-MYERS SQUIBB COMPANY (US) 2013-04-04 — — WO disclosed
EP-1422218-B1 ANTIVIRAL AGENT SHIONOGI & CO (JP) 2012-03-21 — — EP disclosed
EP-2181985-B1 Antiviral Agent SHIONOGI & CO (JP) 2011-10-26 — — EP disclosed
EP-2266958-A1 Antiviral agent SHIONOGI & CO., LTD. (JP) 2010-12-29 — — EP disclosed
EP-2181985-A1 Antiviral Agent SHIONOGI & CO., LTD. (JP) 2010-05-05 — — EP disclosed
US-20040229909-A1 Antiviral agent SHIONOGI & CO., LTD. (JP) 2004-11-18 — — US disclosed
EP-1422218-A1 ANTIVIRAL AGENT SHIONOGI & CO., LTD. (JP) 2004-05-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210322583-A1 RADIO-PHARMACEUTICAL COMPLEXES PTMS, THOP1, PHPT1 TSHR 16/4885KDM4E 4009/4885ALDH1A1 3512/4885
US-20220143229-A1 RADIO-PHARMACEUTICAL COMPLEXES EGFR, MET, ERBB2 TSHR 35/4885KDM4E 1959/4885ALDH1A1 3506/4885
US-20040229909-A1 Antiviral agent ZC3HAV1, ZC3HAV1L, DUT TSHR 4237/4885KDM4E 336/4885ALDH1A1 658/4885
US-11260136-B2 Radio-pharmaceutical complexes EGFR, MET, ERBB2 TSHR 33/4885KDM4E 2112/4885ALDH1A1 3148/4885
US-20140235608-A1 PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE LIPG, PNLIP, LPL TSHR 3766/4885KDM4E 304/4885ALDH1A1 401/4885
US-20190091354-A1 RADIO-PHARMACEUTICAL COMPLEXES EGFR, MET, ERBB2 TSHR 31/4885KDM4E 2143/4885ALDH1A1 3158/4885
US-20190298865-A1 RADIO-PHARMACEUTICAL COMPLEXES FAP, PHPT1, DNPEP TSHR 304/4885KDM4E 1459/4885ALDH1A1 2075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.