Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652394 | 0.86 | HSD11B1 (0.45) | HSD11B1OPRM1CDK4CCND1 | |
| SCHEMBL7652925 | 0.81 | KDM4E (0.41) | HTTHSD11B1KDM4ELMNANPSR1 | |
| SCHEMBL7650590 | 0.81 | KDM4E (0.49) | HTTKDM4ELMNAGAAMAPT | |
| Dimethylamine SCHEMBL7652932 | 0.80 | L3MBTL1 (0.42) | HTTHSD11B1KDM4ELMNANPSR1 | |
| SCHEMBL7659194 | 0.77 | ALDH1A1 (0.51) | HTTKDM4EOPRM1MAPT | |
| SCHEMBL7655309 | 0.75 | CA1 (0.45) | HTTKDM4ELMNANPSR1OPRM1 | |
| SCHEMBL7652545 | 0.75 | ADORA3 (0.49) | HTTLMNAMAPT | |
| SCHEMBL7660359 | 0.74 | MGLL (0.44) | HSD11B1LMNAOPRM1MAPT | |
| SCHEMBL7652883 | 0.74 | OPRM1 (0.41) | OPRM1NR1H2NR1H3 | |
| SCHEMBL7658070 | 0.74 | NPC1 (0.44) | NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492407-B2 | NEUROPROTECTIVE ACTIVITY | BOEHRINGER IMGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |