SCHEMBL765661

SCHEMBL765661

O=C1C[C@@H](NC(=O)OCc2ccccc2)C(=O)N1

nearest known ligand 0.67

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 10/20 0.58
ALDH1A1 P00352 1/20 0.51
GAA P10253 1/20 0.51
CTSL P07711 1/20 0.49
TSHR P16473 1/20 0.49
GPBAR1 Q8TDU6 1/20 0.48
ASAH1 Q13510 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3930648 1.00 NAAA (0.58) NAAAALDH1A1GAACTSLTSHR
SCHEMBL5180974 1.00 NAAA (0.58) NAAAALDH1A1GAACTSLTSHR
SCHEMBL3544056 0.87 CRBN (0.60) NAAAALDH1A1GAACTSLTSHR
SCHEMBL632914 0.87 CRBN (0.60) NAAAALDH1A1GAACTSLTSHR
SCHEMBL5200673 0.87 CRBN (0.60) NAAAALDH1A1GAACTSLTSHR
SCHEMBL24907141 0.85 NAAA (0.51) NAAAGPBAR1ASAH1
SCHEMBL7423681 0.85 NAAA (0.54) NAAAALDH1A1GAACTSL
SCHEMBL14812217 0.84 NAAA (0.50) NAAAALDH1A1GAACTSLTSHR
SCHEMBL14812216 0.84 NAAA (0.50) NAAAALDH1A1GAACTSLTSHR
SCHEMBL1086370 0.83 ALDH1A1 (0.60) NAAAALDH1A1GAACTSLTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118139835-A Method for preparing apoptosis inducer 艾伯维公司 2024-06-04 CN disclosed
EP-4165023-A1 INHIBITORS OF APOL1 AND USE OF THE SAME Vertex Pharmaceuticals Incorporated (US) 2023-04-19 EP disclosed
US-20230014907-A1 INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED 2023-01-19 US disclosed
US-20230014907-A1 INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED 2023-01-19 US disclosed
WO-2021252849-A1 INHIBITORS OF APOL1 AND USE OF THE SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2021-12-16 WO disclosed
US-8729063-B2 3-aminopyrrolidine derivatives as modulators of chemokine receptors INCYTE CORPORATION (US) 2014-05-20 US disclosed
US-20130116230-A1 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2013-05-09 US disclosed
US-8362003-B2 3-aminopyrrolidine derivatives as modulators of chemokine receptors INCYTE CORPORATION (US) 2013-01-29 US disclosed
EP-1565436-B1 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORP (US) 2012-04-25 EP disclosed
EP-2431357-A2 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors Incyte Corporation (US) 2012-03-21 EP disclosed
US-20080009637-A1 Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts BASILEA PHARMACEUTICA AG 2008-01-10 US disclosed
US-7262307-B2 1′-benzyl-3-bromo-[1,3′]bipyrrolidinyl-2-one BASILEA PHARMACEUTICA AG (CH) 2007-08-28 US disclosed
EP-1311518-B1 PREPARATION OF N-PROTECTED-3-PYRROLIDINE-LACTAM SUBSTITUTED PHOSPHONIUM SALTS BASILEA PHARMACEUTICA AG (CH) 2005-11-02 EP disclosed
US-20050070722-A1 1'-Benzyl-3-bromo-[1,3']bipyrrolidinyl-2-one BASILEA PHARMACEUTICA AG (CH) 2005-03-31 US disclosed
US-6828442-B2 Coupling N-benzyl-3-pyrrolidinamine compound with acyl halide; cyclization in presence of a base; reacting with triphenylphosphine to obtain phosphonium salt; reacting with di-tert. -butyl-dicarbonate under hydrogenation conditions BASILEA PHARMACEUTICA AG (CH) 2004-12-07 US disclosed
WO-2004022536-A1 NEW HETEROCYCLIC AMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS LIMITED (US) 2004-03-18 WO disclosed
WO-2004022536-A1 NEW HETEROCYCLIC AMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS LIMITED (US) 2004-03-18 WO disclosed
US-20030195364-A1 Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts BASILEA PHARMACEUTICA AG (CH) 2003-10-16 US disclosed
EP-1311518-A1 PREPARATION OF N-PROTECTED-3-PYRROLIDINE-LACTAM SUBSTITUTED PHOSPHONIUM SALTS Basilea Pharmaceutica AG (CH) 2003-05-21 EP disclosed
WO-2002014332-A1 PREPARATION OF N-PROTECTED-3-PYRROLIDINE-LACTAM SUBSTITUTED PHOSPHONIUM SALTS BASILEA PHARMACEUTICA AG (CH) 2002-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130116230-A1 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS CCR2, CXCR3, CCR5 NAAA 4581/4885ALDH1A1 2447/4885GAA 4876/4885
US-20230014907-A1 INHIBITORS OF APOL1 AND METHODS OF USING SAME APOL1, APOB, NPC1L1 NAAA 3657/4885ALDH1A1 1965/4885GAA 1006/4885
US-20080009637-A1 Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts PNKP, PNISR, CLK3 NAAA 1849/4885ALDH1A1 4439/4885GAA 4126/4885
US-20030195364-A1 Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts PNKP, PHOSPHO1, PTMS NAAA 1885/4885ALDH1A1 4354/4885GAA 4099/4885
US-20050070722-A1 1'-Benzyl-3-bromo-[1,3']bipyrrolidinyl-2-one BRD1, BRD4, BET1 NAAA 3131/4885ALDH1A1 1143/4885GAA 3667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.