Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.51 |
| ▸ | PRTN3 | P24158 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959032 | 0.79 | ALDH1A1 (0.45) | ELANEPRTN3ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL605325 | 0.79 | KDM4E (0.58) | ELANEPRTN3ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13788818 | 0.79 | PDK1 (0.54) | ELANEPRTN3IDO1PDK2KDM4E | |
| SCHEMBL1906473 | 0.79 | CLCN2 (0.53) | ALDH1A1RAB9ACLCN2KDM4ELMNA | |
| SCHEMBL7223562 | 0.78 | MAPT (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AHSP90AB1 | |
| SCHEMBL7223232 | 0.78 | KDM4E (0.54) | ALDH1A1SMN1; SMN2NPC1RAB9ACLCN2 | |
| Hydrochloric Acid SCHEMBL8584876 | 0.78 | KDM4E (0.56) | ELANEPRTN3ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13623623 | 0.78 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4184556 | 0.78 | KDM4E (0.46) | ELANEPRTN3ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7224966 | 0.77 | ADRA1D (0.51) | ALDH1A1CLCN2HPGDMAPTCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919841-B2 | Monoamine reuptake inhibitors | RESEARCH TRIANGLE INSTITUTE (US) | 2021-02-16 | — | — | US | disclosed |
| US-20180215701-A1 | MONOAMINE REUPTAKE INHIBITORS | RES TRIANGLE INST (US) | 2018-08-02 | — | — | US | disclosed |
| US-9562001-B2 | Monoamine reuptake inhibitors | RESEARCH TRIANGLE INSTITUTE (US) | 2017-02-07 | — | — | US | disclosed |
| US-20120071560-A1 | MONOAMINE REUPTAKE INHIBITORS | RESEARCH TRIANGLE INSTITUTE | 2012-03-22 | — | — | US | disclosed |
| EP-1499301-A2 | METHOD OF STABILIZING BUPROPION HYDROCHLORIDE TABLETS | RANBAXY LABORATORIES, LTD. (IN) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086362-A2 | METHOD OF STABILIZING BUPROPION HYDROCHLORIDE TABLETS | RANBAXY LABORATORIES LIMITED (IN) | 2003-10-23 | — | — | WO | disclosed |
| EP-0415613-B1 | Use of sertraline for the treatment of premature ejaculation | PFIZER (US) | 1994-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071560-A1 | MONOAMINE REUPTAKE INHIBITORS | SLC6A2, SLC6A4, SLC6A3 | ELANE 3828/4885PRTN3 1783/4885ALDH1A1 521/4885 |
| US-10919841-B2 | Monoamine reuptake inhibitors | SLC6A2, SLC6A4, SLC6A3 | ELANE 3828/4885PRTN3 1783/4885ALDH1A1 521/4885 |
| US-20180215701-A1 | MONOAMINE REUPTAKE INHIBITORS | SLC6A2, SLC6A4, SLC6A3 | ELANE 3828/4885PRTN3 1783/4885ALDH1A1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.