SCHEMBL7776309

SCHEMBL7776309

Cc1ccc(SNC(=O)Nc2ccc(C(=O)NS(=O)(=O)c3ccccc3O)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.42
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TP53 P04637 2/20 0.41
NFKB1 P19838 1/20 0.41
HTT P42858 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPT P10636 2/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
CA12 O43570 1/20 0.40
CA4 P22748 1/20 0.40
CA6 P23280 1/20 0.40
CA5A P35218 1/20 0.40
CA7 P43166 1/20 0.40
CA13 Q8N1Q1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776171 0.91 PTGES (0.44) MAPTCA1CA2CA9CA12
SCHEMBL8767375 0.86 CA2 (0.42) LMNANPC1RAB9AMAPTCA1
SCHEMBL7643073 0.84 LMNA (0.60) LMNANPC1RAB9ASMN1; SMN2TP53
SCHEMBL7776174 0.80 SIRT1 (0.54) NPC1RAB9ASMN1; SMN2TP53MAPT
SCHEMBL8767632 0.79 LMNA (0.51) LMNANPC1RAB9ATP53CA1
SCHEMBL7770073 0.78 HSD17B10 (0.57) LMNANPC1RAB9ATP53HSD17B10
SCHEMBL7770071 0.77 FLT1 (0.54) LMNANPC1SMN1; SMN2TP53MAPT
SCHEMBL6295396 0.77 KMT2A (0.50) LMNAMAPTCA1CA2CA9
SCHEMBL7774533 0.76 L3MBTL1 (0.47) LMNACA1CA2CA9KMT2A
SCHEMBL23447277 0.75 NPC1 (0.54) LMNANPC1RAB9ASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788889-B1 A thermal sensitive recording sheet JUJO PAPER CO LTD (JP) 2001-08-08 EP disclosed
EP-0788889-A2 A thermal sensitive recording sheet NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1997-08-13 EP disclosed