Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7788988 | 0.89 | ALDH1A1 (0.47) | RXFP1ALDH1A1KCNK3KCNK9GAA | |
| SCHEMBL7789410 | 0.86 | ALDH1A1 (0.57) | RXFP1ALDH1A1KCNK9GAALMNA | |
| SCHEMBL7785656 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KCNK9GAALMNAMEN1 | |
| SCHEMBL7787608 | 0.79 | MAPKAPK2 (0.40) | ALDH1A1KCNK3KCNK9GAALMNA | |
| SCHEMBL7780394 | 0.77 | ALDH1A1 (0.67) | ALDH1A1GAALMNAMEN1POLB | |
| SCHEMBL27530263 | 0.77 | KCNK3 (0.41) | KCNK3KCNK9MEN1POLBKMT2A | |
| SCHEMBL7787169 | 0.75 | ALDH1A1 (0.58) | RXFP1ALDH1A1KCNK9GAALMNA | |
| SCHEMBL7789205 | 0.74 | GPR88 (0.48) | ALDH1A1GAALMNAMEN1POLB | |
| SCHEMBL7787683 | 0.73 | MAPKAPK2 (0.45) | MAPK1CYP3A4MAPKAPK2 | |
| SCHEMBL7787601 | 0.73 | MAPKAPK2 (0.45) | MAPK1CYP3A4MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |