SCHEMBL7793224

SCHEMBL7793224

CCCC[N]c1ccc(Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.40
LMNA P02545 2/20 0.40
NOS3 P29474 2/20 0.39
NOS1 P29475 2/20 0.39
NOS2 P35228 2/20 0.39
KCNH2 Q12809 4/20 0.36
ALDH1A1 P00352 2/20 0.36
POLB P06746 2/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HPGD P15428 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HTR3E A5X5Y0 2/20 0.35
HTR3B O95264 2/20 0.35
HTR3A P46098 2/20 0.35
HTR3D Q70Z44 2/20 0.35
HTR3C Q8WXA8 2/20 0.35
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7794055 0.80 SCN5A (0.44) SMN1; SMN2NOS3NOS1NOS2HPGD
SCHEMBL49576 0.77 LTA4H (0.38) SMN1; SMN2NOS3NOS1NOS2ALDH1A1
SCHEMBL7794049 0.77 HTR3A (0.39) SMN1; SMN2LMNANOS3NOS1NOS2
SCHEMBL1735291 0.77 NOS3 (0.44) SMN1; SMN2LMNANOS3NOS1NOS2
SCHEMBL2097207 0.75 CA12 (0.44) SMN1; SMN2LMNANOS3NOS1NOS2
SCHEMBL2094118 0.75 CYP2C9 (0.53) LMNAALDH1A1CYP2D6CYP2C19GAA
SCHEMBL10990336 0.75 LMNA (0.40) SMN1; SMN2LMNANOS3NOS1NOS2
SCHEMBL8178048 0.74 NOS1 (0.44) SMN1; SMN2LMNANOS3NOS1NOS2
SCHEMBL8176728 0.74 TSHR (0.46) NOS3NOS1ALDH1A1CYP2A6
Dodecane SCHEMBL28192320 0.73 SMN1; SMN2 (0.56) SMN1; SMN2LMNAKCNH2ALDH1A1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1150963-A1 SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Aventis Pharma Deutschland GmbH (DE) 2001-11-07 EP disclosed
WO-2000046214-A1 SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-08-10 WO disclosed