Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799736 | 0.76 | L3MBTL1 (0.40) | MAPTSYKL3MBTL1HDAC2HDAC3 | |
| SCHEMBL7137802 | 0.74 | CTSK (0.44) | CTSKSYKHDAC2HDAC3HDAC1 | |
| SCHEMBL7139230 | 0.70 | CTSD (0.46) | MAPTCTSKL3MBTL1HDAC1MEN1 | |
| SCHEMBL27700677 | 0.69 | CETP (0.51) | HDAC2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL13334305 | 0.68 | MAPT (0.55) | MAPTSYKL3MBTL1KLK7KLK5 | |
| SCHEMBL7797006 | 0.67 | L3MBTL1 (0.45) | CTSKL3MBTL1HDAC2HDAC3HDAC1 | |
| SCHEMBL6182061 | 0.67 | CTSS (0.54) | CTSK | |
| SCHEMBL20147826 | 0.66 | ALDH1A1 (0.50) | MAPTCTSKL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL3422485 | 0.66 | CPB2 (0.33) | CTSK | |
| SCHEMBL20330727 | 0.65 | SYK (0.45) | CTSKSYKL3MBTL1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |