Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.52 |
| ▸ | BCHE | P06276 | 5/20 | 0.52 |
| ▸ | MAOB | P27338 | 9/20 | 0.49 |
| ▸ | MAOA | P21397 | 6/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071910 | 0.89 | ACHE (0.53) | ACHEBCHEMAOBMAOAHRH3 | |
| SCHEMBL8068050 | 0.88 | XDH (0.48) | MAOAHRH3KDM4E | |
| SCHEMBL7827131 | 0.88 | PARP1 (0.50) | ACHEBCHEMAOBMAOAHRH3 | |
| SCHEMBL8067124 | 0.86 | MAOA (0.52) | ACHEMAOAHRH3KDM4EALDH1A1 | |
| SCHEMBL7816229 | 0.85 | MAOA (0.47) | MAOBMAOA | |
| SCHEMBL7827564 | 0.84 | MAOA (0.47) | MAOBMAOA | |
| SCHEMBL7824605 | 0.84 | CTSV (0.43) | MAOA | |
| Trifluoroacetic Acid SCHEMBL8057460 | 0.84 | ACHE (0.48) | ACHEBCHEMAOBMAOA | |
| Trifluoroacetic Acid SCHEMBL8067000 | 0.83 | XDH (0.44) | HRH3KDM4EALDH1A1 | |
| SCHEMBL7829082 | 0.83 | CTSV (0.44) | MAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |