Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.33 |
| ▸ | TUBB4A known ✓ | P04350 | 2/20 | 0.32 |
| ▸ | TUBB known ✓ | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B known ✓ | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A known ✓ | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B known ✓ | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 known ✓ | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A known ✓ | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 2/20 | 0.32 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 2/20 | 0.32 |
| ▸ | TUBA1A known ✓ | Q71U36 | 2/20 | 0.32 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 2/20 | 0.32 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 2/20 | 0.32 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 2/20 | 0.32 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL7850429 | 0.97 | GAA (0.39) | GAAHDAC3FKBP1ACES2CES1 | |
| SCHEMBL7940864 | 0.93 | GAA (0.41) | GAAHDAC3FKBP1ACES2CES1 | |
| Styrene SCHEMBL987788 | 0.86 | LMNA (0.44) | HDAC3CES2CES1LMNAEGFR | |
| SCHEMBL10604712 | 0.83 | GAA (0.43) | GAAHDAC3FKBP1ACES2CES1 | |
| Styrene SCHEMBL7849011 | 0.83 | GAA (0.38) | GAAHDAC3FKBP1ACES2CES1 | |
| Styrene SCHEMBL7948135 | 0.83 | TDP1 (0.50) | GAAHDAC3CES2CES1LMNA | |
| Styrene SCHEMBL8862982 | 0.82 | LMNA (0.41) | HDAC3CES2CES1LMNAEGFR | |
| Styrene SCHEMBL8471452 | 0.82 | LMNA (0.41) | GAAHDAC3CES2CES1LMNA | |
| Styrene SCHEMBL8862498 | 0.82 | LMNA (0.41) | HDAC3CES2CES1LMNAEGFR | |
| Styrene SCHEMBL258132 | 0.82 | LMNA (0.47) | HDAC3CES2CES1LMNAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268103-B1 | Toner processes | XEROX CORPORATION | 2001-07-31 | — | — | US | disclosed |
| US-6190820-B1 | Toner processes | XEROX CORPORATION | 2001-02-20 | — | — | US | disclosed |