Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913113 | 0.94 | SLC9A1 (0.37) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| Cadaverine Tartrate SCHEMBL7902842 | 0.89 | SLC9A1 (0.33) | SLC9A1 | |
| SCHEMBL7916322 | 0.87 | SLC9A1 (0.33) | SLC9A1 | |
| Maleic Acid SCHEMBL7916788 | 0.81 | SLC9A1 (0.54) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| Maleic Acid SCHEMBL7912919 | 0.77 | SMN1; SMN2 (0.33) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| Fumaric Acid SCHEMBL7912855 | 0.77 | SMN1; SMN2 (0.33) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| SCHEMBL8136306 | 0.77 | ALDH1A1 (0.38) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| SCHEMBL7913350 | 0.76 | SLC9A1 (0.37) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| SCHEMBL7912931 | 0.74 | SLC9A1 (0.59) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 | |
| SCHEMBL7913304 | 0.74 | ACHE (0.42) | LMNAMAPTSMN1; SMN2SLC9A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |