SCHEMBL7935254

SCHEMBL7935254

COC(=O)c1ccc(CNC(C)=O)cc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40
TSHR P16473 1/20 0.39
CDK1 P06493 1/20 0.39
KMT2A Q03164 1/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 2/20 0.38
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
NAMPT P43490 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18896036 0.85 KMT2A (0.43) SMN1; SMN2TSHRKMT2AKDM4EALDH1A1
SCHEMBL7933510 0.83 CA2 (0.52) SMN1; SMN2TSHRCDK1KMT2AMAPT
SCHEMBL7933507 0.83 LOXL2 (0.45) SMN1; SMN2TSHRKMT2AMAPTKDM4E
SCHEMBL7735941 0.83 CA1 (0.39) SMN1; SMN2TSHRCDK1KMT2AMAPT
SCHEMBL7735252 0.81 CA2 (0.40) TSHRKMT2AMAPTKDM4EALDH1A1
SCHEMBL21962901 0.81 KMT2A (0.39) SMN1; SMN2TSHRKMT2AMAPTKDM4E
SCHEMBL22409153 0.81 PTPN1 (0.43) SMN1; SMN2KMT2AMAPTKDM4EALDH1A1
SCHEMBL30884146 0.81 PTPN1 (0.43) SMN1; SMN2KMT2AMAPTKDM4EALDH1A1
SCHEMBL7727241 0.81 ALDH1A1 (0.39) SMN1; SMN2TSHRKMT2AMAPTALDH1A1
SCHEMBL7736172 0.80 ALDH1A1 (0.39) SMN1; SMN2TSHRCDK1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9693558-B2 Process for preparing a novel crystalline form of mesosulfuron-methyl and use of the same ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2017-07-04 US disclosed
US-20170156330-A1 PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF MESOSULFURON-METHYL AND USE OF THE SAME ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2017-06-08 US disclosed
US-20170156332-A1 SYNERGISTIC HERBICIDAL COMPOSITION AND USE THEREOF ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (CN) 2017-06-08 US disclosed
WO-2017092477-A1 PROCESS FOR PREPARING NOVEL CRYSTALLINE FORM OF MESOSULFURON-METHYL AND USE THEREOF ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (CN) 2017-06-08 WO disclosed
US-9661851-B1 Synergistic herbicidal composition and use thereof ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2017-05-30 US disclosed
US-6239306-B1 Phenylsulfonylureas, processes for their preparation, and their use as herbicides and plant growth regulations HOECHST SCHERING AGREVO GMBH (DE) 2001-05-29 US disclosed
US-5925597-A PRE-EMERGENCE AND POST-EMERGENCE HERBICIDES HOECHST SCHERING AGREVO GMBH (DE) 1999-07-20 US disclosed
EP-0723534-B1 PHENYLSULFONYL UREAS, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-07-29 EP disclosed
US-5648315-A Phenylsulfonylureas, Processes for their-preparation, and their use as herbicides and plant growth regulators HOECHST SCHERING AGREVO GMBH (DE) 1997-07-15 US disclosed
EP-0723534-A1 PHENYLSULFONYL UREAS, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1996-07-31 EP disclosed
WO-1995010507-A1 PHENYLSULFONYL UREAS, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1995-04-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170156330-A1 PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF MESOSULFURON-METHYL AND USE OF THE SAME MPST, STS, SCLY SMN1; SMN2 1357/4885TSHR 2925/4885CDK1 983/4885
US-20170156332-A1 SYNERGISTIC HERBICIDAL COMPOSITION AND USE THEREOF DDT, AS3MT, METTL3 SMN1; SMN2 2947/4885TSHR 1755/4885CDK1 3768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.