Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961722 | 0.86 | ABCB1 (0.38) | SLC6A4 | |
| SCHEMBL7953976 | 0.78 | SLC6A2 (0.38) | DRD3SLC6A2SLC6A4CCR5 | |
| Phenylacetic Acid SCHEMBL7961720 | 0.74 | P2RX7 (0.30) | — | |
| SCHEMBL7965779 | 0.72 | ITGA4 (0.33) | DRD3CCR5 | |
| SCHEMBL7953266 | 0.71 | CCR5 (0.34) | DRD3SLC6A2SLC6A4CCR5SIGMAR1 | |
| SCHEMBL7965744 | 0.69 | HTR1A (0.36) | DRD3SLC6A4 | |
| SCHEMBL7965995 | 0.67 | — | — | |
| SCHEMBL7963764 | 0.66 | MEN1 (0.35) | DRD3CCR5SIGMAR1 | |
| SCHEMBL7967126 | 0.66 | ABCB1 (0.39) | DRD3 | |
| SCHEMBL7965454 | 0.66 | OPRL1 (0.36) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |