Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963015 | 0.86 | OPRM1 (0.44) | ALDH1A1MAPTNPC1RAB9AOPRM1 | |
| SCHEMBL7962696 | 0.84 | LTA4H (0.35) | ALDH1A1MAPTNPC1RAB9AOPRM1 | |
| SCHEMBL7962741 | 0.84 | PDE10A (0.42) | MAPTNPC1RAB9AOPRM1OPRD1 | |
| SCHEMBL7962212 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAPTNPC1RAB9AOPRM1 | |
| SCHEMBL7965112 | 0.79 | LMNA (0.39) | ALDH1A1MAPTNPC1RAB9AOPRM1 | |
| Sulfuric Acid SCHEMBL7968955 | 0.79 | THRB (0.36) | OPRM1DRD2DRD3THRB | |
| Heptanoate SCHEMBL7966354 | 0.78 | LTA4H (0.38) | ALDH1A1MAPTNPC1RAB9AOPRM1 | |
| SCHEMBL7963392 | 0.78 | ADRB2 (0.35) | OPRM1OPRD1OPRK1OPRL1TP53 | |
| SCHEMBL7953343 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTNPC1RAB9AOPRM1 | |
| Fumaric Acid SCHEMBL7966209 | 0.76 | MAPT (0.38) | ALDH1A1MAPTNPC1DRD2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |