Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958185 | 0.89 | CYP11B1 (0.39) | AGTR1AGTR2CYP11B1CYP11B2IDO1 | |
| SCHEMBL7969213 | 0.86 | FABP4 (0.37) | CYP11B1CYP11B2KDM4ENPC1ALDH1A1 | |
| SCHEMBL7973956 | 0.86 | CYP11B1 (0.42) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL7987447 | 0.74 | GPR119 (0.31) | — | |
| SCHEMBL16160246 | 0.70 | FNTA (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL7968966 | 0.69 | FNTA (0.44) | CYP11B1CYP11B2 | |
| SCHEMBL7958104 | 0.66 | CYP11B1 (0.58) | CYP11B1CYP11B2IDO1KDM4ENPC1 | |
| SCHEMBL7984767 | 0.63 | KDM4C (0.36) | CYP11B1CYP11B2IDO1KDM4EALDH1A1 | |
| SCHEMBL683433 | 0.61 | AGTR1 (0.54) | AGTR1AGTR2CYP11B1CYP11B2 | |
| SCHEMBL729589 | 0.60 | ALDH1A1 (0.57) | KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009127-A1 | BENZOXAZINE DERIVATIVES AND THEIR THERAPEUTIC USE | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |