Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991565 | 0.93 | TSHR (0.49) | KMT2AFGFR1FGFR4PKMGAA | |
| SCHEMBL7973987 | 0.87 | FGFR1 (0.45) | KMT2AFGFR1FGFR4PKMGAA | |
| SCHEMBL7974223 | 0.86 | RAB9A (0.46) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7984273 | 0.85 | PPARG (0.40) | FGFR1FGFR4GSK3AGSK3BADORA2A | |
| SCHEMBL7987598 | 0.84 | RIOK2 (0.41) | KMT2AMEN1FGFR1FGFR4RAB9A | |
| SCHEMBL7984711 | 0.84 | ABCC8 (0.44) | FGFR1FGFR4NPC1RAB9AKDM4E | |
| SCHEMBL7987555 | 0.84 | GAA (0.47) | KMT2AMEN1PKMGAATSHR | |
| SCHEMBL7986400 | 0.83 | YTHDC1 (0.47) | KMT2AMEN1FGFR1FGFR4GAA | |
| SCHEMBL7987930 | 0.82 | KMT2A (0.57) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL7974162 | 0.82 | KDM4E (0.52) | KMT2AFGFR1FGFR4SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |