Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974547 | 0.89 | HPGD (0.40) | TRPM8ADORA3YTHDC1 | |
| SCHEMBL7984868 | 0.88 | NR1H4 (0.42) | NR1H4ABCC8KCNJ11EPHX2NR1I2 | |
| SCHEMBL7974277 | 0.88 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11EGLN3SERPINE1 | |
| SCHEMBL7991400 | 0.87 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11EPHX2TRPM8 | |
| SCHEMBL7985010 | 0.87 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11EGLN3SERPINE1 | |
| SCHEMBL7992267 | 0.86 | ICMT (0.44) | NR1H4ABCC8KCNJ11EGLN3SERPINE1 | |
| SCHEMBL7974490 | 0.86 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11NR1I2ADORA3 | |
| SCHEMBL7988016 | 0.85 | HDAC1 (0.44) | NR1H4ABCC8KCNJ11SERPINE1ADORA3 | |
| SCHEMBL7985597 | 0.85 | SERPINE1 (0.46) | NR1H4ABCC8KCNJ11SERPINE1 | |
| SCHEMBL7974237 | 0.81 | KIF11 (0.42) | NR1H4ABCC8KCNJ11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |