SCHEMBL7983270

SCHEMBL7983270

O=C([O-])c1cccc(Br)c1I.[Na+]

nearest known ligand 0.45

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 5/20 0.38
CA1 known ✓ P00915 4/20 0.38
CA4 known ✓ P22748 1/20 0.35
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HPGD P15428 1/20 0.45
PRNP P04156 1/20 0.36
KMT2A Q03164 3/20 0.34
MEN1 O00255 2/20 0.34
MAOB P27338 1/20 0.34
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
FABP4 P15090 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8679482 0.83 ALDH1A1 (0.58) ALDH1A1KDM4EHPGDCA2CA1
SCHEMBL3266996 0.79 PRNP (0.50) ALDH1A1KDM4EHPGDCA2CA1
Zinc Ion SCHEMBL31152542 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDCA2CA4
SCHEMBL8613576 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDCA2CA4
SCHEMBL8678737 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDCA2CA4
SCHEMBL30459298 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDCA2CA4
Potassium Ion SCHEMBL2112433 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDCA2CA4
SCHEMBL7983272 0.78 PRNP (0.49) ALDH1A1KDM4EHPGDCA2CA1
SCHEMBL21296300 0.78 METAP2 (0.50) ALDH1A1KDM4EHPGDPRNP
SCHEMBL1950873 0.78 ALDH1A1 (0.42) ALDH1A1HPGDPRNPKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6290926-B1 CATALYSIS OF CARBON MONOXIDE CONVERSION VIA THE WATER-GAS SHIFT REACTION STUDIENGESELLSCHAFT KOHLE MBH (DE) 2001-09-18 US disclosed
EP-0946573-A1 CATALYSTS MADE FROM TRANSITION METAL COMPOUNDS AND 4,5-DIPHOSPHINOACRIDINE-LIGANDS Studiengesellschaft Kohle mbH (DE) 1999-10-06 EP disclosed
WO-1998027101-A1 NOVEL CATALYSTS MADE FROM TRANSITION METAL COMPOUNDS AND 4,5-DIPHOSPHINOACRIDINE-LIGANDS STUDIENGESELLSCHAFT KOHLE MBH (DE) 1998-06-25 WO disclosed