Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PARN | O95453 | 1/20 | 0.33 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974157 | 0.93 | BRD4 (0.44) | BRD4KAT8PARNCNOT7PAX8 | |
| SCHEMBL7984731 | 0.90 | ABCC8 (0.39) | BRD4ABCC8KCNJ11NR1H4KAT8 | |
| SCHEMBL7988789 | 0.87 | BRD4 (0.40) | BRD4ABCC8KCNJ11NR1H4KAT8 | |
| SCHEMBL7985482 | 0.83 | PAX8 (0.43) | BRD4PARNCNOT7PAX8 | |
| SCHEMBL7974282 | 0.82 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4PARNCNOT7 | |
| SCHEMBL7985012 | 0.81 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4PARNCNOT7 | |
| SCHEMBL7991403 | 0.81 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4GNRHRSCN9A | |
| SCHEMBL7985602 | 0.81 | SERPINE1 (0.45) | ABCC8KCNJ11SERPINE1 | |
| SCHEMBL7992270 | 0.80 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4PARNCNOT7 | |
| SCHEMBL7974492 | 0.80 | ABCC8 (0.47) | ABCC8KCNJ11NR1H4PARNCNOT7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |