SCHEMBL8038136

SCHEMBL8038136

O=C(O)C(C(=O)O)(C(=O)O)N1CCNCCNCCN(Cc2ccccc2)CC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.62
ALDH1A1 P00352 7/20 0.52
LMNA P02545 4/20 0.52
KMT2A Q03164 3/20 0.52
CXCR4 P61073 5/20 0.49
MEN1 O00255 2/20 0.47
CYP2C9 P11712 1/20 0.47
TSHR P16473 1/20 0.47
CYP2C19 P33261 1/20 0.47
HIF1A Q16665 1/20 0.47
CHRM2 P08172 1/20 0.47
CHRM1 P11229 1/20 0.47
ADRA2C P18825 1/20 0.47
CCR2 P41597 1/20 0.47
CXCL12 P48061 1/20 0.47
BLM P54132 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
HRH3 Q9Y5N1 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
KDM4E B2RXH2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8992770 0.88 CXCR4 (0.47) SIGMAR1ALDH1A1LMNAKMT2ACXCR4
SCHEMBL10574436 0.84 ALDH1A1 (0.54) ALDH1A1LMNATDP1SMN1; SMN2KDM4E
SCHEMBL8992842 0.82 CXCR4 (0.41) SIGMAR1ALDH1A1LMNAKMT2ACXCR4
Bicarbonate SCHEMBL21981463 0.82 SIGMAR1 (0.85) SIGMAR1ALDH1A1LMNAKMT2ACXCR4
SCHEMBL9538814 0.82 SIGMAR1 (0.92) SIGMAR1ALDH1A1LMNAKMT2ACXCR4
SCHEMBL7573306 0.81 SIGMAR1 (0.96) SIGMAR1ALDH1A1LMNAKMT2ACXCR4
SCHEMBL7062479 0.81 SIGMAR1 (0.96) SIGMAR1ALDH1A1KMT2ACXCR4MEN1
SCHEMBL8145866 0.81 SIGMAR1 (0.96) SIGMAR1ALDH1A1LMNAKMT2ACXCR4
SCHEMBL10063607 0.81 SIGMAR1 (0.96) SIGMAR1ALDH1A1KMT2ACXCR4MEN1
Piperazine SCHEMBL28115310 0.81 SIGMAR1 (0.96) SIGMAR1ALDH1A1KMT2ACXCR4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0232751-B1 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECANE AND ANALOGS E.R. Squibb & Sons, Inc. (US) 1991-09-11 EP claimed
US-4885363-A RADIOPHARMACEUTICAL IMAGING; MEDICAL DIAGNOSIS E. R. SQUIBB & SONS, INC. (US) 1989-12-05 US claimed
EP-0292689-A2 Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs BRACCO INTERNATIONAL B.V. (NL) 1988-11-30 EP claimed
EP-0232751-A1 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs E.R. Squibb & Sons, Inc. (US) 1987-08-19 EP claimed
US-6143274-A IMAGING MAMMALIAN TISSUE UTILIZING A NON-IONIC COMPLEX OF A PARAMAGNETIC ION OF LANTHANIDE ELEMENT AND A MACROCYCLIC CHELATING AGENT BRACCO DIAGNOSTICS, INC. 2000-11-07 US disclosed
US-5846519-A Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs BRACCO DIAGNOSTICS INC. (US) 1998-12-08 US disclosed
US-5674470-A Method for imaging mammalian tissue using 1-substituted- 4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs BRACCO DIAGNOSTICS INC. (US) 1997-10-07 US disclosed
EP-0292689-B1 Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs BRACCO INT BV (NL) 1996-07-31 EP disclosed
US-5474756-A Chelate compound of a paramagnetic ion of lanthanide element BRACCO INTERNATIONAL B.V. (NL) 1995-12-12 US disclosed
EP-0394394-B1 MANGANESE(II) CHELATES NYCOMED SALUTAR INC (US) 1995-01-18 EP disclosed
US-5155224-A Protonated, insoluble magnetic resonance imaging contrast agents SALUTAR, INC. (US) 1992-10-13 US disclosed
EP-0232751-B1 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECANE AND ANALOGS E.R. Squibb & Sons, Inc. (US) 1991-09-11 EP disclosed
US-4978763-A Novel manganese(II) DTPA chelate SALUTAR, INC. (US) 1990-12-18 US disclosed
EP-0394394-A1 MANGANESE(II) CHELATES. SALUTAR INC (US) 1990-10-31 EP disclosed
EP-0369497-A1 Manganese (II) chelates SALUTAR, INC. (US) 1990-05-23 EP disclosed
WO-1990003975-A1 MANGANESE(II) CHELATES SALUTAR, INC. (US) 1990-04-19 WO disclosed
US-4889931-A TREATING MANGANESE OXIDE WITH CHELATING AGENTS SALUTAR, INC. (US) 1989-12-26 US disclosed
US-4885363-A RADIOPHARMACEUTICAL IMAGING; MEDICAL DIAGNOSIS E. R. SQUIBB & SONS, INC. (US) 1989-12-05 US disclosed
EP-0292689-A2 Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs BRACCO INTERNATIONAL B.V. (NL) 1988-11-30 EP disclosed
EP-0232751-A1 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs E.R. Squibb & Sons, Inc. (US) 1987-08-19 EP disclosed