Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323146 | 0.80 | AKT1 (0.50) | RAB9ANPC1KMT2A | |
| SCHEMBL6235763 | 0.73 | RIPK1 (0.50) | HSD11B1TRPM8TDP1 | |
| SCHEMBL8064136 | 0.73 | ALOX5 (0.46) | HCAR3TRPM8RAB9ANPC1CHRM2 | |
| SCHEMBL8337464 | 0.72 | GAA (0.43) | KMT2A | |
| SCHEMBL12265806 | 0.70 | HSD11B1 (0.52) | HCAR3HSD11B1HCAR2TRPM8RAB9A | |
| SCHEMBL12810929 | 0.69 | LTA4H (0.45) | HCAR3HSD11B1HCAR2TRPM8KDM4C | |
| SCHEMBL12669758 | 0.68 | RAB9A (0.54) | RAB9ANPC1TDP1KMT2A | |
| SCHEMBL976949 | 0.68 | DRD2 (0.49) | HCAR3HSD11B1HCAR2OPRM1OPRD1 | |
| SCHEMBL23032133 | 0.68 | TRPM8 (0.53) | HCAR3HSD11B1HCAR2OPRD1TRPM8 | |
| Methyl Alcohol SCHEMBL11612623 | 0.68 | TDP1 (0.49) | RAB9ANPC1TDP1KMT2ASLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103721-A | TREATMENT OF STROKE ANOXIA; ANTIHYPERGLYCEMIC,-ISCHEMIC AND -EPILEPTIC AGENTS | ZENECA LIMITED (GB) | 2000-08-15 | — | — | US | disclosed |