Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 11/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.40 |
| ▸ | TOP2A | P11388 | 3/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8080918 | 0.90 | KEAP1 (0.45) | KEAP1NFE2L2CA12CA1CA2 | |
| SCHEMBL8470816 | 0.89 | KEAP1 (0.42) | KEAP1NFE2L2CA12CA1CA2 | |
| SCHEMBL8076269 | 0.88 | ALDH1A1 (0.42) | KEAP1NFE2L2TOP2ATOP2BKDM4E | |
| SCHEMBL8066342 | 0.86 | ALDH1A1 (0.38) | KEAP1NFE2L2CA12CA1CA2 | |
| SCHEMBL8076560 | 0.83 | MMP3 (0.42) | KEAP1NFE2L2TOP2ATOP2BLMNA | |
| SCHEMBL9407911 | 0.81 | LMNA (0.49) | KEAP1NFE2L2TOP2ATOP2BKDM4E | |
| SCHEMBL9407919 | 0.81 | LMNA (0.43) | TOP2ATOP2BKDM4ELMNATP53 | |
| Bromide SCHEMBL8469666 | 0.78 | KEAP1 (0.48) | KEAP1NFE2L2LMNA | |
| SCHEMBL8469225 | 0.78 | ALDH1A1 (0.48) | KEAP1NFE2L2KDM4ELMNATP53 | |
| Bromide SCHEMBL8076530 | 0.77 | KEAP1 (0.46) | KEAP1NFE2L2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330050-B1 | Special chemiluminescent acridine derivatives and their use in luminescence immunoassays | DADE BEHRING MARBURG GMBH (DE) | 2000-08-23 | — | — | EP | disclosed |
| EP-0602524-A1 | Chemiluminescence marked sequences and their use in sequence testing | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0330050-A2 | Special chemiluminescent acridine derivatives and their use in luminescence immunoassays | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-30 | — | — | EP | disclosed |