SCHEMBL8087708

SCHEMBL8087708

CCCN(CCC)S(=O)(=O)N(CCc1cccc(C(F)(F)F)c1)C(=O)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.45
LMNA P02545 4/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
RAB9A P51151 1/20 0.41
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
MAPT P10636 2/20 0.41
TSHR P16473 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
PDK1 Q15118 1/20 0.40
NR4A2 P43354 1/20 0.40
S1PR1 P21453 1/20 0.40
GRK5 P34947 1/20 0.40
CDK8 P49336 1/20 0.40
S1PR5 Q9H228 1/20 0.40
NR1I2 O75469 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8090727 0.90 TRPM8 (0.51) TRPM8LMNASMN1; SMN2MEN1KMT2A
SCHEMBL8092409 0.85 HSD11B1 (0.47) SMN1; SMN2RAB9AOPRM1DRD3MLYCD
SCHEMBL8092470 0.82 TAS2R14 (0.49)
SCHEMBL8079204 0.78 CNR2 (0.47) LMNASMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL8079261 0.78 HSD11B1 (0.45) LMNAMEN1KMT2AHTR1AADRA2A
SCHEMBL3579012 0.76 TRPM8 (0.47) TRPM8LMNAMEN1KMT2ARAB9A
SCHEMBL3232453 0.76 TRPM8 (0.53) TRPM8LMNAMEN1KMT2AMAPT
SCHEMBL8092540 0.76 TAS2R14 (0.50) RAB9AMAPTNPSR1ALDH1A1
SCHEMBL8090715 0.74 TAS2R14 (0.53) LMNAMEN1KMT2ARAB9AMAPT
SCHEMBL8086489 0.74 ALDH1A1 (0.49) SMN1; SMN2MEN1KMT2ARAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047670-A1 AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS ELI LILLY AND COMPANY LIMITED (GB) 2000-11-02 EP disclosed
WO-1999036398-A1 AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS ELI LILLY AND COMPANY LIMITED (GB) 1999-07-22 WO disclosed