Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090786 | 0.86 | SGK1 (0.37) | MTORKDREPHB4TEK | |
| SCHEMBL8083654 | 0.85 | HSD11B1 (0.33) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8104712 | 0.80 | IDO1 (0.40) | MTORPIK3CDPIK3CAPIK3CG | |
| SCHEMBL8083416 | 0.79 | PIK3R1 (0.39) | PIK3CA | |
| SCHEMBL8091143 | 0.79 | KIF11 (0.36) | PIK3CDPIK3CAPRSS1 | |
| SCHEMBL8091710 | 0.78 | PIK3CD (0.36) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8091293 | 0.78 | MAPT (0.42) | MTORPIK3CAPIK3CG | |
| SCHEMBL8082685 | 0.78 | IDO1 (0.40) | MTORPIK3CAPIK3CG | |
| SCHEMBL8083616 | 0.78 | ATR (0.42) | MTORPIK3CDPIK3CA | |
| SCHEMBL8090868 | 0.78 | MTOR (0.38) | MTORPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |