Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CCR3 | P51677 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087704 | 0.91 | SMN1; SMN2 (0.59) | ACHEMEN1KMT2ACCR3LTA4H | |
| SCHEMBL4512639 | 0.90 | LTA4H (0.60) | ACHEMEN1KMT2ACCR3SIGMAR1 | |
| SCHEMBL3271398 | 0.90 | LTA4H (0.60) | ACHEMEN1KMT2ACCR3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL18038825 | 0.88 | LTA4H (0.58) | ACHEMEN1KMT2ACCR3SIGMAR1 | |
| SCHEMBL12082512 | 0.84 | ALDH1A1 (0.56) | ACHEMEN1KMT2ALTA4HHRH3 | |
| SCHEMBL791901 | 0.84 | MEN1 (0.55) | ACHEMEN1KMT2ASIGMAR1LTA4H | |
| SCHEMBL1428200 | 0.83 | KDM4E (0.53) | ACHESIGMAR1LTA4HBCHEHRH3 | |
| SCHEMBL995966 | 0.83 | LTA4H (0.49) | ACHEMEN1KMT2ACCR3LTA4H | |
| SCHEMBL28375594 | 0.83 | LTA4H (0.52) | ACHEMEN1KMT2ALTA4HHRH3 | |
| SCHEMBL3158273 | 0.83 | LMNA (0.57) | ACHESIGMAR1LTA4HHRH3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017093208-A1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-06-08 | — | — | WO | disclosed |
| US-9181220-B2 | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use | RIGEL PHARMACEUTICALS, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| CN-101903310-B | Method for producing organic compound | M TECH CO LTD | 2014-12-17 | — | — | CN | disclosed |
| US-20140179738-A1 | N-Substituted-Heterocycloalkyloxybenzamide Compounds and Methods of Use | RIGEL PHARMACEUTICALS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| CN-102099358-B | Compound with serotoninergic activity, process for preparing same and pharmaceutical composition comprising same | ACRAF | 2014-01-22 | — | — | CN | disclosed |
| US-20130303516-A1 | NOVEL TRIAZINE COMPOUNDS | SPHAERA PHARMA PTE. LTD. (SG) | 2013-11-14 | — | — | US | disclosed |
| US-8569340-B2 | AMPK-activating piperidinyloxypyiridine carboxamide and sulfonamide compounds and methods for using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8486941-B2 | Phenyl amino pyrimidine compounds and uses thereof | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2013-07-16 | — | — | US | disclosed |
| US-8486941-B2 | Phenyl amino pyrimidine compounds and uses thereof | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2013-07-16 | — | — | US | disclosed |
| US-20110230663-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | ALEMBIC LIMITED (IN) | 2011-09-22 | — | — | US | disclosed |
| US-20110130286-A1 | Piperazine Compounds with Herbicidal Effect | BASF SE (DE) | 2011-06-02 | — | — | US | disclosed |
| US-20110105759-A1 | PROCESS FOR PRODUCING 1-BENZYL-4- [ (5,6-DIMETHOXY-1-INDANONE)-2-YLIDENE] METHYLPIPERIDINE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-05-05 | — | — | US | disclosed |
| US-7902235-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | GLAXOSMITHKLINE LLC | 2010-08-05 | — | — | US | disclosed |
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | GLAXOSMITHKLINE LLC | 2010-08-05 | — | — | US | disclosed |
| US-20090203752-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| CN-1918165-A | Azabicyclic heterocycles as cannabinoid receptor modulators | BRISTOL MYERS SQUIBB CO (US) | 2007-02-21 | — | — | CN | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | JAK2, JAK1, JAK3 | ACHE 4874/4885MEN1 4037/4885KMT2A 835/4885 |
| US-20110230663-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | BCHE, ACHE, PSEN1 | ACHE 2/4885MEN1 2600/4885KMT2A 650/4885 |
| US-20110105759-A1 | PROCESS FOR PRODUCING 1-BENZYL-4- [ (5,6-DIMETHOXY-1-INDANONE)-2-YLIDENE] METHYLPIPERIDINE | CMPK1, DHPS, IMPA1 | ACHE 2594/4885MEN1 1085/4885KMT2A 1909/4885 |
| US-20090203752-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | NSUN2, UPF1, NSUN3 | ACHE 4710/4885MEN1 2836/4885KMT2A 1404/4885 |
| US-20140179738-A1 | N-Substituted-Heterocycloalkyloxybenzamide Compounds and Methods of Use | PRKAG2, PRKAB2, PRKAG1 | ACHE 1781/4885MEN1 3006/4885KMT2A 740/4885 |
| US-20130303516-A1 | NOVEL TRIAZINE COMPOUNDS | MTOR, MAPKAP1, PIK3R5 | ACHE 4885/4885MEN1 1736/4885KMT2A 2416/4885 |
| US-20110130286-A1 | Piperazine Compounds with Herbicidal Effect | CAT, DDT, CIP2A | ACHE 240/4885MEN1 4738/4885KMT2A 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.